Crystallin, mu (CRYM) (AA 215-315) antibody

Details for Product No. ABIN393252
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Antigen
Synonyms CRYM, zgc:158843, DFNA40, THBP
Epitope
AA 215-315
(9), (8), (7), (4), (3), (3), (2), (2), (2), (1)
Reactivity
Human
(39), (12), (4)
Host
Mouse
(25), (23)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(48), (20), (17), (8), (8), (4), (4), (4), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN393252
450.00 $
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Immunogen CRYM (NP_001879, 215 a.a. ~ 315 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1C6
Isotype IgG1 kappa
Specificity CRYM (NP_001879, 215 a.a. ~ 315 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CRYM
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 33776 DA
Gene ID 12406
NCBI Accession NP_001879
Research Area Neurology, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. Multiple alternatively spliced transcript variants have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Crystallin, mu (CRYM) (AA 215-315) antibody CRYM monoclonal antibody (M09), clone 1C6. Western Blot analysis of CRYM expression in K-562. Detection limit for recombinant GST tagged CRYM is approximately 0.03 ng/mL as a capture antibody.
anti-Crystallin, mu (CRYM) (AA 215-315) antibody (2) anti-Crystallin, mu (CRYM) (AA 215-315) antibody (Image 2)
Background publications Martins-de-Souza, Gattaz, Schmitt et al.: "Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia." in: Journal of psychiatric research, Vol. 43, Issue 11, pp. 978-86, 2009 (PubMed).

Martins-de-Souza, Gattaz, Schmitt et al.: "Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia." in: European archives of psychiatry and clinical neuroscience, Vol. 259, Issue 3, pp. 151-63, 2009 (PubMed).

Malinowska, Cavarretta, Susani et al.: "Identification of mu-crystallin as an androgen-regulated gene in human prostate cancer." in: The Prostate, Vol. 69, Issue 10, pp. 1109-18, 2009 (PubMed).

Al-Kafaji, Malik: "Hyperglycemia induces elevated expression of thyroid hormone binding protein in vivo in kidney and heart and in vitro in mesangial cells." in: Biochemical and biophysical research communications, Vol. 391, Issue 4, pp. 1585-91, 2010 (PubMed).

Martins-de-Souza, Maccarrone, Wobrock et al.: "Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia." in: Journal of psychiatric research, Vol. 44, Issue 16, pp. 1176-89, 2010 (PubMed).

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