|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Crystallin, mu (CRYM) antibody
|Synonyms||THBP, DFNA40, MGC108623, CRYM, MGC137343, zgc:158843|
Alternatives ELISA, Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||CRYM (NP_001879, 215 a.a. ~ 315 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: DFNA40, THBP crystallin, mu|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||CRYM (NP_001879, 215 a.a. ~ 315 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||33776 DA|
Background: Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. Multiple alternatively spliced transcript variants have been found for this gene.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Neurology, Cell Structure|
|Restrictions||For Research Use only|
Martins-de-Souza, Gattaz, Schmitt et al.: "Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia." in: Journal of psychiatric research, Vol. 43, Issue 11, pp. 978-86, 2009 (PubMed).
Martins-de-Souza, Gattaz, Schmitt et al.: "Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia." in: European archives of psychiatry and clinical neuroscience, Vol. 259, Issue 3, pp. 151-63, 2009 (PubMed).
Malinowska, Cavarretta, Susani et al.: "Identification of mu-crystallin as an androgen-regulated gene in human prostate cancer." in: The Prostate, Vol. 69, Issue 10, pp. 1109-18, 2009 (PubMed).
Al-Kafaji, Malik: "Hyperglycemia induces elevated expression of thyroid hormone binding protein in vivo in kidney and heart and in vitro in mesangial cells." in: Biochemical and biophysical research communications, Vol. 391, Issue 4, pp. 1585-91, 2010 (PubMed).
Martins-de-Souza, Maccarrone, Wobrock et al.: "Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia." in: Journal of psychiatric research, Vol. 44, Issue 16, pp. 1176-89, 2010 (PubMed).
|Hosts||Rabbit (11), Mouse (5)|
|Reactivities||Human (15), Rat (Rattus) (6), Mouse (Murine) (4), Cow (Bovine) (2), Cat (Feline) (1), Chicken (1), Dog (Canine) (1)|
|Applications||Western Blotting (WB) (17), ELISA (8), Immunohistochemistry (IHC) (8), Immunofluorescence (IF) (3), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (3), Dot Blot (DB) (1), Flow Cytometry (FACS) (1), Immunoprecipitation (IP) (1)|
|Epitopes||Transcript Variant 1 (2), Internal Region (1), N-Term (1)|