serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 17-411) antibody

Details for Product No. ABIN393254
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Antigen
Synonyms CG9453, Dmel\\CG9453, Serp2, Sp4, Spn4, Spn4A, dSerp2, sp4, spn4, SERPINI1, pi12, neuroserpin, AI837402, Ns, PI-12, PI12, Spi17, raPIT5a
Epitope
AA 17-411
(12), (9), (8), (7), (7), (5), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(73), (47), (24), (12), (12), (12), (12), (1)
Host
Mouse
(60), (17), (12), (5), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(11), (6), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(68), (50), (13), (13), (10), (8), (7), (6), (5), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393254
450.00 $
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Immunogen SERPINI1 (AAH18043, 17 a.a. ~ 411 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1D10
Isotype IgG1 kappa
Specificity SERPINI1 (AAH18043, 17 a.a. ~ 411 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SERPINI1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 46427 DA
Gene ID 12406
Research Area Neurology, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 17-411) antibody SERPINI1 monoclonal antibody (M01), clone 1D10 Western Blot analysis of SERPINI1 expression in HeLa on formalin-fixed paraffin-embedded human cerebral cortex (antibody concentration 3 µg/mL).
anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 17-411) antibody (2) anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 17-411) antibody (Image 2)
Background publications Ricagno, Caccia, Sorrentino et al.: "Human neuroserpin: structure and time-dependent inhibition." in: Journal of molecular biology, Vol. 388, Issue 1, pp. 109-21, 2009 (PubMed).

Rajaraman, Brenner, Butler et al.: "Common variation in genes related to innate immunity and risk of adult glioma." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 5, pp. 1651-8, 2009 (PubMed).

Davies, Miranda, Roussel et al.: "Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response." in: The Journal of biological chemistry, Vol. 284, Issue 27, pp. 18202-9, 2009 (PubMed).

Rajaraman, Brenner, Neta et al.: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010 (PubMed).

Han, Lan, Park et al.: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010 (PubMed).

Validation Images
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