Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) (AA 424-523) antibody

Details for Product No. ABIN393258
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Antigen
Synonyms Kv1.3-glyb, kv1.3, Kv1.3B, kcna3b-a, HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3, Kca1-3, Kv1.3, Mk-3, cKv1.1
Epitope
AA 424-523
(40), (33), (19), (17), (16), (15), (8), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(95), (67), (52), (2)
Host
Mouse
(71), (43)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (5), (5), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(92), (63), (35), (35), (32), (10), (8), (3), (2), (2), (2), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Immunogen KCNA3 (AAH35059, 424 a.a. ~ 523 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1D8
Isotype IgG1 kappa
Specificity KCNA3 (AAH35059, 424 a.a. ~ 523 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name KCNA3 (KCNA3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 58304 DA
Gene ID 12406
Research Area Cell Structure, Cell Cycle, Neurology
Application Notes Western blot = 1:500-1000
Comment

Background: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) (AA 424-523) antibody KCNA3 monoclonal antibody (M01), clone 1D8 Western Blot analysis of KCNA3 expression ...
anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) (AA 424-523) antibody (2) anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) (AA 424-523) antibody (Image 2)
Background publications Wang, Lee, Johnson et al.: "Activated T-cells inhibit neurogenesis by releasing granzyme B: rescue by Kv1.3 blockers." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 14, pp. 5020-7, 2010 (PubMed).

Tu, Deutsch: "A folding zone in the ribosomal exit tunnel for Kv1.3 helix formation." in: Journal of molecular biology, Vol. 396, Issue 5, pp. 1346-60, 2010 (PubMed).

Feng, Zhang, Ma et al.: "[Kv1.3 potassium channel expression changes after CD4(+) and subsets CD28(null)/CD28(+)T cells activation in peripheral blood of patients with acute coronary syndrome]." in: Zhonghua xin xue guan bing za zhi, Vol. 37, Issue 7, pp. 599-604, 2009 (PubMed).

Nicolaou, Neumeier, Takimoto et al.: "Differential calcium signaling and Kv1.3 trafficking to the immunological synapse in systemic lupus erythematosus." in: Cell calcium, Vol. 47, Issue 1, pp. 19-28, 2010 (PubMed).

Poulopoulou, Markakis, Davaki et al.: "Aberrant modulation of a delayed rectifier potassium channel by glutamate in Alzheimer's disease." in: Neurobiology of disease, Vol. 37, Issue 2, pp. 339-48, 2010 (PubMed).

Validation Images
Catalog No. ABIN393258
450.00 $
Plus shipping costs $45.00
Quantity
Price
0.1 mg
450.00 $

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