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Details for Product No. ABIN393258

Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) antibody

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Antigen
Synonyms Kv1.3-glyb, MK3, HGK5, HLK3, PCN3, HPCN3, KV1.3, HUKIII, Mk-3, Kv1.3, Kca1-3, kv1.3, Kv1.3B, kcna3b-a, cKv1.1
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN393258
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen KCNA3 (AAH35059, 424 a.a. ~ 523 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1D8
Isotype IgG1 kappa
Specificity KCNA3 (AAH35059, 424 a.a. ~ 523 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name KCNA3
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 58304 DA
Gene ID 12406
Research Area Cell Structure, Cell Cycle, Neurology
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Poulopoulou, Markakis, Davaki et al.: "Aberrant modulation of a delayed rectifier potassium channel by glutamate in Alzheimer's disease." in: Neurobiology of disease, Vol. 37, Issue 2, pp. 339-48, 2010 (PubMed).

Nicolaou, Neumeier, Takimoto et al.: "Differential calcium signaling and Kv1.3 trafficking to the immunological synapse in systemic lupus erythematosus." in: Cell calcium, Vol. 47, Issue 1, pp. 19-28, 2010 (PubMed).

Feng, Zhang, Ma et al.: "[Kv1.3 potassium channel expression changes after CD4(+) and subsets CD28(null)/CD28(+)T cells activation in peripheral blood of patients with acute coronary syndrome]." in: Zhonghua xin xue guan bing za zhi, Vol. 37, Issue 7, pp. 599-604, 2009 (PubMed).

Tu, Deutsch: "A folding zone in the ribosomal exit tunnel for Kv1.3 helix formation." in: Journal of molecular biology, Vol. 396, Issue 5, pp. 1346-60, 2010 (PubMed).

Wang, Lee, Johnson et al.: "Activated T-cells inhibit neurogenesis by releasing granzyme B: rescue by Kv1.3 blockers." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 14, pp. 5020-7, 2010 (PubMed).

Alternatives for antigen "Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3)", type "Antibodies"
Hosts (60), (9)
Reactivities (66), (43), (41), (24), (24), (12), (12)
Applications (39), (26), (23), (20), (13), (13), (4), (3), (3), (2), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (17), (8), (6), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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