Distal-Less Homeobox 4 (DLX4) (AA 1-99) antibody

Details for Product No. ABIN393260
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Antigen
Synonyms DLX4, BP1, DLX7, DLX8, DLX9, Dlx-4, Dlx7
Epitope
AA 1-99
(10), (7), (7), (5), (4), (3), (2), (1), (1), (1), (1)
Reactivity
Human
(66), (22), (19), (16), (12), (1), (1)
Host
Mouse
(63), (7)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(57), (17), (14), (13), (10), (5), (4), (4), (3), (2), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN393260
450.00 $
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Immunogen DLX4 (AAH16145, 1 a.a. ~ 99 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1F11
Isotype IgG2a kappa
Specificity DLX4 (AAH16145, 1 a.a. ~ 99 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name DLX4
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 26263 DA
Gene ID 12406
Research Area Neurology, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Distal-Less Homeobox 4 (DLX4) (AA 1-99) antibody Western blot analysis of DLX4 over-expressed 293 cell line, cotransfected with DLX4 Validated Chimera RNAi used as specificity and loading control. Western Blot analysis of DLX4 expression in transfected 293T cell line by DLX4 monoclonal antibody (M01), clone 1F11. Lane 1: DLX4 transfected lysate(26 KDa). Lane 2: Non-transfected lysate.
anti-Distal-Less Homeobox 4 (DLX4) (AA 1-99) antibody (2) anti-Distal-Less Homeobox 4 (DLX4) (AA 1-99) antibody (Image 2)
Background publications Schwartz, Man, Rezaei et al.: "BP1, a homeoprotein, is significantly expressed in prostate adenocarcinoma and is concordant with prostatic intraepithelial neoplasia." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 22, Issue 1, pp. 1-6, 2008 (PubMed).

Vieira, McHenry, Daack-Hirsch et al.: "Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts." in: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 10, Issue 9, pp. 668-74, 2008 (PubMed).

Cavalli, Man, Schwartz et al.: "Amplification of the BP1 homeobox gene in breast cancer." in: Cancer genetics and cytogenetics, Vol. 187, Issue 1, pp. 19-24, 2008 (PubMed).

Man, Schwartz, Levine et al.: "BP1, a putative signature marker for inflammatory breast cancer and tumor aggressiveness." in: Cancer biomarkers : section A of Disease markers, Vol. 5, Issue 1, pp. 9-17, 2009 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Validation Images
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