|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Huntingtin Interacting Protein 1 (HIP1) antibody
Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||HIP1 (NP_005329, 928 a.a. ~ 1038 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: huntingtin interacting protein 1|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||HIP1 (NP_005329, 928 a.a. ~ 1038 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||116221 DA|
Background: The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. An alternative splice variant of this gene has been described but its full length sequence has not been determined.
|Synonyms||ILWEQ, MGC126506, CG10971, DmelCG10971, KIAA4113, MGC27616, mKIAA4113, 2610109B09Rik, A930014B11Rik, E130315I21Rik, HYPB, SET2, HIF-1, KMT3A, HBP231, HSPC069, p231HBP, FLJ16420, FLJ22472, FLJ23184, FLJ45883, FLJ46217, KIAA1732, hip1, MGC78813, HIP1|
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Cell Structure, Neurology|
|Restrictions||For Research Use only|
Niu, Ybe: "Crystal structure at 2.8 A of Huntingtin-interacting protein 1 (HIP1) coiled-coil domain reveals a charged surface suitable for HIP1 protein interactor (HIPPI)." in: Journal of molecular biology, Vol. 375, Issue 5, pp. 1197-205, 2008 (PubMed).
Wilbur, Chen, Manalo et al.: "Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain." in: The Journal of biological chemistry, Vol. 283, Issue 47, pp. 32870-9, 2008 (PubMed).
Gottfried, Ehrlich, Ashery: "HIP1 exhibits an early recruitment and a late stage function in the maturation of coated pits." in: Cellular and molecular life sciences : CMLS, Vol. 66, Issue 17, pp. 2897-911, 2009 (PubMed).
Han, Zheng, Cui et al.: "Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus." in: Nature genetics, Vol. 41, Issue 11, pp. 1234-7, 2009 (PubMed).
Wilbur, Hwang, Brodsky et al.: "Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain." in: Acta crystallographica. Section D, Biological crystallography, Vol. 66, Issue Pt 3, pp. 314-8, 2010 (PubMed).
|Hosts||Rabbit (24), Mouse (12)|
|Reactivities||Human (36), Rat (Rattus) (23), Mouse (Murine) (21), Chicken (19), Dog (Canine) (19), Horse (Equine) (18), Rabbit (18), Cat (Feline) (1), Cow (Bovine) (1)|
|Applications||Western Blotting (WB) (21), Immunofluorescence (IF) (16), ELISA (11), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (IHC) (3), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1)|
|Conjugates||Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)|
|Epitopes||C-Term (2), Center (1)|