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Details for Product No. ABIN393267

Doublecortin (DCX) antibody

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Synonyms 18C15.5, DC, DBCN, LISX, SCLH, XLIS, Dbct, DCX
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN393267
Quantity 0.1 mg
450.00 $   Plus shipping costs $45.00
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Immunogen DCX (AAH27925, 1 a.a. ~ 361 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1G12
Isotype IgG1 kappa
Specificity DCX (AAH27925, 1 a.a. ~ 361 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name DCX
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 44925 DA
Gene ID 12406
Research Area Neurology, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia (double cortex syndrome) in females and lissencephaly (smooth brain syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Santra, Santra, Roberts et al.: "Doublecortin induces mitotic microtubule catastrophe and inhibits glioma cell invasion." in: Journal of neurochemistry, Vol. 108, Issue 1, pp. 231-45, 2008 (PubMed).

Chiaretti, Barone, Riccardi et al.: "NGF, DCX, and NSE upregulation correlates with severity and outcome of head trauma in children." in: Neurology, Vol. 72, Issue 7, pp. 609-16, 2009 (PubMed).

Evangelisti, Florian, Massimi et al.: "MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 23, Issue 12, pp. 4276-87, 2009 (PubMed).

Le Hellard, Håvik, Espeseth et al.: "Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities." in: PLoS ONE, Vol. 4, Issue 10, pp. e7534, 2009 (PubMed).

Dijkmans, van Hooijdonk, Fitzsimons et al.: "The doublecortin gene family and disorders of neuronal structure." in: Central nervous system agents in medicinal chemistry, Vol. 10, Issue 1, pp. 32-46, 2010 (PubMed).

Alternatives for antigen "Doublecortin (DCX)", type "Antibodies"
Hosts (68), (12), (4)
Reactivities (80), (57), (53), (29), (26), (25), (2), (1)
Applications (60), (42), (20), (13), (12), (8), (6), (4), (2), (1), (1), (1), (1), (1)
Conjugates (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (12), (5), (5), (5), (4), (2), (2), (2), (2), (1), (1), (1), (1)