Opiate Receptor-Like 1 (OPRL1) (AA 110-213) antibody

Details for Product No. ABIN393277
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Antigen
Synonyms KOR-3, NOCIR, OOR, ORL1, KOR3, LC132, MOR-C, OFQR, Oprl, XOR1, OPRL, ORGC, morc
Epitope
AA 110-213
(2), (2), (2), (1), (1)
Reactivity
Human
(34), (23), (17), (17), (17), (17), (5), (1)
Host
Mouse
(30), (3), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA
(15), (15), (10), (8), (5), (4), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393277
450.00 $
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Immunogen OPRL1 (AAH38433, 110 a.a. ~ 213 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2A11
Isotype IgG2a kappa
Specificity OPRL1 (AAH38433, 110 a.a. ~ 213 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name OPRL1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 40693 DA
Gene ID 12406
Research Area Cell Structure, Neurology
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Two transcript variants encoding the same protein have been found for this gene.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Opiate Receptor-Like 1 (OPRL1) (AA 110-213) antibody Detection limit for recombinant GST tagged OPRL1 is approximately 3 ng/mL as a capture antibody.
Background publications de Krom, Staal, Ophoff et al.: "A common variant in DRD3 receptor is associated with autism spectrum disorder." in: Biological psychiatry, Vol. 65, Issue 7, pp. 625-30, 2009 (PubMed).

Kuzmin, Bazov, Sheedy et al.: "Expression of pronociceptin and its receptor is downregulated in the brain of human alcoholics." in: Brain research, Vol. 1305 Suppl, pp. S80-5, 2009 (PubMed).

Tabakoff, Saba, Printz et al.: "Genetical genomic determinants of alcohol consumption in rats and humans." in: BMC biology, Vol. 7, pp. 70, 2009 (PubMed).

Briant, Nielsen, Proudnikov et al.: "Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addiction in Caucasians." in: Psychiatric genetics, Vol. 20, Issue 2, pp. 65-72, 2010 (PubMed).

Ghebranious, Mukesh, Giampietro et al.: "A pilot study of gene/gene and gene/environment interactions in Alzheimer disease." in: Clinical medicine & research, Vol. 9, Issue 1, pp. 17-25, 2011 (PubMed).

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