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Details for Product No. ABIN393277

Opiate Receptor-Like 1 (OPRL1) antibody

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Synonyms KOR-3, NOCIR, OOR, ORL1, KOR3, LC132, MOR-C, ORGC, Oprl, XOR1, morc, OFQR, OPRL
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives ELISA
Pubmed 5 references available
Catalog no. ABIN393277
Quantity 0.1 mg
450.00 $   Plus shipping costs $45.00
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Immunogen OPRL1 (AAH38433, 110 a.a. ~ 213 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2A11
Isotype IgG2a kappa
Specificity OPRL1 (AAH38433, 110 a.a. ~ 213 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name OPRL1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 40693 DA
Gene ID 12406
Research Area Cell Structure, Neurology
Application Notes ELISA ~~ 1ug/ml~3ng/ml

Background: The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Two transcript variants encoding the same protein have been found for this gene.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications de Krom, Staal, Ophoff et al.: "A common variant in DRD3 receptor is associated with autism spectrum disorder." in: Biological psychiatry, Vol. 65, Issue 7, pp. 625-30, 2009 (PubMed).

Kuzmin, Bazov, Sheedy et al.: "Expression of pronociceptin and its receptor is downregulated in the brain of human alcoholics." in: Brain research, Vol. 1305 Suppl, pp. S80-5, 2009 (PubMed).

Tabakoff, Saba, Printz et al.: "Genetical genomic determinants of alcohol consumption in rats and humans." in: BMC biology, Vol. 7, pp. 70, 2009 (PubMed).

Briant, Nielsen, Proudnikov et al.: "Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addiction in Caucasians." in: Psychiatric genetics, Vol. 20, Issue 2, pp. 65-72, 2010 (PubMed).

Ghebranious, Mukesh, Giampietro et al.: "A pilot study of gene/gene and gene/environment interactions in Alzheimer disease." in: Clinical medicine & research, Vol. 9, Issue 1, pp. 17-25, 2011 (PubMed).

Alternatives for antigen "Opiate Receptor-Like 1 (OPRL1)", type "Antibodies"
Hosts (28), (3)
Reactivities (31), (20), (17), (17), (17), (17), (3)
Applications (15), (12), (10), (9), (6), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (2), (1), (1), (1)