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Protocadherin gamma Subfamily A, 2 (PCDHGA2) (AA 223-332) antibody

Details for Product No. ABIN393281, Supplier: Log in to see
Antigen
  • CDHF7
  • CDHR8
  • FAT
  • hFat1
  • ME5
  • mKIAA0588
  • PCDH-GAMMA-A2
Epitope
AA 223-332
8
3
3
1
Reactivity
Human
13
Host
Mouse
11
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
Application
Western Blotting (WB)
12
12
1
1
1
1
Supplier
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Immunogen PCDHGA2 (NP_061738, 223 a.a. ~ 332 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2A7
Isotype IgG2a kappa
Specificity PCDHGA2 (NP_061738, 223 a.a. ~ 332 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name PCDHGA2 (PCDHGA2 Antibody Abstract)
Background This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Synonyms: PCDHGAMMAA2 protocadherin gamma subfamily A, 2
Molecular Weight 101484 DA
Gene ID 56113
NCBI Accession NP_061738
Research Area Cell Structure, Neurology
Application Notes Western blot = 1:500-1000
Comment

Background: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Restrictions For Research Use only
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Protocadherin gamma Subfamily A, 2 (PCDHGA2) (AA 223-332) antibody (ABIN393281) Western blot analysis of PCDHGA2 over-expressed 293 cell line, cotransfected with PCD...
Immunohistochemistry (IHC) image for anti-Protocadherin gamma Subfamily A, 2 (PCDHGA2) (AA 223-332) antibody (ABIN393281) anti-Protocadherin gamma Subfamily A, 2 (PCDHGA2) (AA 223-332) antibody (Image 2)
Background publications Rose, Behm, Drgon, Johnson, Uhl: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010

Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002

Wu, Zhang, Cheng, Kim, Grimwood, Schmutz, Dickson, Noonan, Zhang, Myers, Maniatis: "Comparative DNA sequence analysis of mouse and human protocadherin gene clusters." in: Genome research, Vol. 11, Issue 3, pp. 389-404, 2001

Nollet, Kools, van Roy: "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members." in: Journal of molecular biology, Vol. 299, Issue 3, pp. 551-72, 2000

Yagi, Takeichi: "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity." in: Genes & development, Vol. 14, Issue 10, pp. 1169-80, 2000