Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1) (AA 1-274) antibody

Details for Product No. ABIN393293
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Antigen
Synonyms OLR1, LOX1, Olr1, CLEC8A, LOXIN, SCARE1, SLOX1, LOX-1, SR-EI, Scare1, Oldlr1, Oldr1, PLOX-1
Epitope
AA 1-274
(10), (7), (5), (5), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(91), (40), (37), (29), (17), (2)
Host
Mouse
(68), (25), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application
ELISA
(56), (36), (24), (13), (12), (6), (5), (5), (4), (4), (3), (3), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393293
450.00 $
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Immunogen OLR1 (AAH22295, 1 a.a. ~ 274 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2C9
Isotype IgG2a kappa
Specificity OLR1 (AAH22295, 1 a.a. ~ 274 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name OLR1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 30959 DA
Gene ID 12406
Research Area Cell Signaling, Neurology, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1) (AA 1-274) antibody Detection limit for recombinant GST tagged OLR1 is approximately 3 ng/mL as a capture antibody.
Background publications Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Wang, Fu, Xie et al.: "Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population." in: Journal of human genetics, Vol. 55, Issue 8, pp. 490-4, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Man, Baum, Fu et al.: "Genetic polymorphisms of Chinese patients with ischemic stroke and concurrent stenoses of extracranial and intracranial vessels." in: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, Vol. 17, Issue 10, pp. 1244-7, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

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