Necdin Homolog (Mouse) (NDN) (AA 222-322) antibody

Details for Product No. ABIN393296
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Antigen
Synonyms LOC574323, AI528698, Peg6, NDN, HsT16328, PWCR
Epitope
AA 222-322
(8), (8), (4), (3), (2), (2), (1), (1), (1)
Reactivity
Human
(40), (13), (12), (12), (12), (12)
Host
Mouse
(30), (10)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(29), (14), (9), (8), (7), (6), (5), (2), (2), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN393296
450.00 $
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Immunogen NDN (NP_002478, 222 a.a. ~ 322 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2D11
Isotype IgG2a kappa
Specificity NDN (NP_002478, 222 a.a. ~ 322 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name NDN
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 36086 DA
Gene ID 12406
NCBI Accession NP_002478
Research Area Neurology, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Necdin Homolog (Mouse) (NDN) (AA 222-322) antibody NDN monoclonal antibody (M07), clone 2D11 Western Blot analysis of NDN expression in U-2 OS.
Background publications Lu, Dollé, Imholz et al.: "Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations." in: Journal of lipid research, Vol. 49, Issue 12, pp. 2582-9, 2008 (PubMed).

de Krom, Staal, Ophoff et al.: "A common variant in DRD3 receptor is associated with autism spectrum disorder." in: Biological psychiatry, Vol. 65, Issue 7, pp. 625-30, 2009 (PubMed).

Liu, Wang, Zhang et al.: "Nogo-A inhibits necdin-accelerated neurite outgrowth by retaining necdin in the cytoplasm." in: Molecular and cellular neurosciences, Vol. 41, Issue 1, pp. 51-61, 2009 (PubMed).

Yoshikawa: "[Regulation of neuronal development by the imprinted gene Necdin]." in: No to hattatsu. Brain and development, Vol. 41, Issue 3, pp. 214-8, 2009 (PubMed).

Chapman, Knowles: "Necdin: a multi functional protein with potential tumor suppressor role?" in: Molecular carcinogenesis, Vol. 48, Issue 11, pp. 975-81, 2009 (PubMed).

Validation Images
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