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CES2 (AA 514-622) antibody

Details for Product No. ABIN393310
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Antigen
Synonyms CE-2, CES2A1, PCE-2, iCE, Ces2, ces2A3, EG436059, Gm5744
Epitope
AA 514-622
(9), (8), (7), (5), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(50), (5), (4), (3)
Host
Mouse
(39), (16), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(57), (33), (23), (9), (9), (6), (4), (4), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393310
450.00 $
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Immunogen CES2 (NP_003860, 514 a.a. ~ 622 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2H7
Isotype IgG2b kappa
Specificity CES2 (NP_003860, 514 a.a. ~ 622 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 61807 DA
Gene ID 12406
UniProt NP_003860
Research Area Neurology, Metabolism, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-CES2 (AA 514-622) antibody CES2 monoclonal antibody (M01), clone 2H7. Western Blot analysis of CES2 expression in HepG2. Detection limit for recombinant GST tagged CES2 is approximately 1 ng/mL as a capture antibody.
anti-CES2 (AA 514-622) antibody (2) anti-CES2 (AA 514-622) antibody (Image 2)
Background publications Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Holmes, Cox, VandeBerg: "Mammalian carboxylesterase 3: comparative genomics and proteomics." in: Genetica, Vol. 138, Issue 7, pp. 695-708, 2010 (PubMed).

Howard, Hsu, Grzywacz et al.: "Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE." in: Environmental health perspectives, Vol. 118, Issue 10, pp. 1395-9, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Validation Images
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