rho GTPase Activating Protein 2 antibody

Antigen: rho GTPase Activating Protein 2

Clonality: Monoclonal (3A3)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393312

Additional Information

Alternative name: CHN1

Gene ID: 1123

Immunogen: CHN1 (AAH11393, 91 a.a. ~ 201 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 3A3

Description: Other names: ARHGAP2, CHN, RHOGAP2 chimerin (chimaerin) 1

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: CHN1 (AAH11393, 91 a.a. ~ 201 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 53172 DA

Comments:

Background: This gene encodes GTPase-activating protein for p21-rac and a phorbol ester receptor. It plays an important role in ocular motor axon pathfinding. Heterozygous missense mutations in this gene cause Duane's retraction syndrome 2 (DURS2). Multiple transcript variants encoding different isoforms have been found for this gene.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Neurology, Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged CHN1 is approximately 0.1ng/ml as a capture antibody.

Publications

Product: Murillo-Correa, Kon-Jara, Engle et al.: "Clinical features associated with an I126M alpha2-chimaerin mutation in a family with autosomal-dominant Duane retraction syndrome." in: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus, Vol. 13, Issue 3, pp. 245-8, 2009 (PubMed).

Miyake, Andrews, Fan et al.: "CHN1 mutations are not a common cause of sporadic Duane's retraction syndrome." in: American journal of medical genetics. Part A, Vol. 152A, Issue 1, pp. 215-7, 2009 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Dick, Meyers, Aliev et al.: "Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 6, pp. 1179-88, 2010 (PubMed).

Volk, Fricke, Strobl et al.: "Analysis of the CHN1 gene in patients with various types of congenital ocular motility disorders." in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, Vol. 248, Issue 9, pp. 1351-7, 2010 (PubMed).