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TPP1 antibody (Tripeptidyl Peptidase I) (AA 195-305)

Details for Product anti-TPP1 Antibody No. ABIN393313, Supplier: Log in to see
Antigen
  • cln2
  • fa01b09
  • im:7149243
  • wu:fa01b09
  • CLN2
  • LPIC
  • TPP-1
  • TPP-I
  • Cln2
Alternatives
anti-Human TPP1 antibody for ELISA
Epitope
AA 195-305
17
14
6
4
4
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
80
22
19
3
3
1
1
1
Host
Mouse
63
12
7
Clonality (Clone)
Monoclonal ()
Conjugate
This TPP1 antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
64
33
18
15
11
4
3
2
2
2
2
1
Supplier
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Immunogen TPP1 (AAH14863, 195 a.a. ~ 305 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B1
Isotype IgG1 kappa
Specificity TPP1 (AAH14863, 195 a.a. ~ 305 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TPP1 (TPP1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 61248 DA
Gene ID 12406
Research Area Neurology, Cell Structure
Pathways Cell Division Cycle
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-TPP1 antibody (Tripeptidyl Peptidase I) (AA 195-305) (ABIN393313) TPP1 monoclonal antibody (M01), clone 3B1 Western Blot analysis of TPP1 expression in...
Immunohistochemistry (IHC) image for anti-TPP1 antibody (Tripeptidyl Peptidase I) (AA 195-305) (ABIN393313) anti-Tripeptidyl Peptidase I (TPP1) (AA 195-305) antibody (Image 2)
Background publications Souweidane, Fraser, Arkin et al.: "Gene therapy for late infantile neuronal ceroid lipofuscinosis: neurosurgical considerations." in: Journal of neurosurgery. Pediatrics, Vol. 6, Issue 2, pp. 115-22, 2010 (PubMed).

Latrick, Cech: "POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation." in: The EMBO journal, Vol. 29, Issue 5, pp. 924-33, 2010 (PubMed).

Goldberg-Stern, Halevi, Marom et al.: "Late infantile neuronal ceroid lipofuscinosis: a new mutation in Arabs." in: Pediatric neurology, Vol. 41, Issue 4, pp. 297-300, 2009 (PubMed).

Autefage, Albinet, Garcia et al.: "Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner." in: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11507-16, 2009 (PubMed).

Kousi, Siintola, Dvorakova et al.: "Mutations in CLN7/MFSD8 are a common cause of variant late-infantile neuronal ceroid lipofuscinosis." in: Brain : a journal of neurology, Vol. 132, Issue Pt 3, pp. 810-9, 2009 (PubMed).