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TPP1 antibody (Tripeptidyl Peptidase I) (AA 195-305)

Details for Product anti-TPP1 Antibody No. ABIN393313, Supplier: Login to see New
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Synonyms cln2, fa01b09, im:7149243, wu:fa01b09, CLN2, LPIC, TPP-1, TPP-I, Cln2
AA 195-305
(17), (14), (6), (5), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(82), (22), (19), (3), (3), (1), (1), (1)
(64), (12), (8)
Clonality (Clone)
Monoclonal ()
This TPP1 antibody is un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(66), (34), (18), (15), (11), (4), (3), (2), (2), (2), (2), (1)
Pubmed 5 references available
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Quantity 0.1 mg
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Availability Will be delivered in 8 to 11 Business Days
Immunogen TPP1 (AAH14863, 195 a.a. ~ 305 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B1
Isotype IgG1 kappa
Specificity TPP1 (AAH14863, 195 a.a. ~ 305 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TPP1 (TPP1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 61248 DA
Gene ID 12406
Research Area Neurology, Cell Structure
Pathways Cell Division Cycle
Application Notes Western blot = 1:500-1000

Background: This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-TPP1 antibody (Tripeptidyl Peptidase I) (AA 195-305) (ABIN393313) TPP1 monoclonal antibody (M01), clone 3B1 Western Blot analysis of TPP1 expression in...
Immunohistochemistry (IHC) image for anti-TPP1 antibody (Tripeptidyl Peptidase I) (AA 195-305) (ABIN393313) anti-Tripeptidyl Peptidase I (TPP1) (AA 195-305) antibody (Image 2)
Background publications Souweidane, Fraser, Arkin et al.: "Gene therapy for late infantile neuronal ceroid lipofuscinosis: neurosurgical considerations." in: Journal of neurosurgery. Pediatrics, Vol. 6, Issue 2, pp. 115-22, 2010 (PubMed).

Latrick, Cech: "POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation." in: The EMBO journal, Vol. 29, Issue 5, pp. 924-33, 2010 (PubMed).

Goldberg-Stern, Halevi, Marom et al.: "Late infantile neuronal ceroid lipofuscinosis: a new mutation in Arabs." in: Pediatric neurology, Vol. 41, Issue 4, pp. 297-300, 2009 (PubMed).

Autefage, Albinet, Garcia et al.: "Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner." in: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11507-16, 2009 (PubMed).

Kousi, Siintola, Dvorakova et al.: "Mutations in CLN7/MFSD8 are a common cause of variant late-infantile neuronal ceroid lipofuscinosis." in: Brain : a journal of neurology, Vol. 132, Issue Pt 3, pp. 810-9, 2009 (PubMed).

Catalog No. ABIN393313
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