Glutamate-Ammonia Ligase (GLUL) (AA 274-374) antibody

Details for Product No. ABIN393316
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Antigen
Synonyms glul, MGC64262, ATGSR2, F15E12.14, F15E12_14, GLUTAMINE SYNTHETASE, glutamine synthase clone F11, GLNS, GS, PIG43, PIG59, Glns, p42, glns, pig43, pig59, xgs
Epitope
AA 274-374
(12), (6), (6), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(47), (20), (18), (4), (2), (1), (1), (1), (1), (1)
Host
Mouse
(43), (16)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (3), (1), (1), (1), (1)
Application
Western Blotting (WB)
(52), (34), (18), (14), (8), (7), (6), (3), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393316
450.00 $
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Immunogen GLUL (NP_002056, 274 a.a. ~ 374 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B6
Isotype IgG1 kappa
Specificity GLUL (NP_002056, 274 a.a. ~ 374 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GLUL
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 42064 DA
Gene ID 12406
NCBI Accession NP_002056
Research Area Cell Signaling, Cell Cycle, Neurology, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling. This gene is expressed during early fetal stages, and plays an important role in controlling body pH by removing ammonia from circulation. Mutations in this gene are associated with congenital glutamine deficiency. Several alternatively spliced transcript variants have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Glutamate-Ammonia Ligase (GLUL) (AA 274-374) antibody GLUL monoclonal antibody (M02), clone 3B6. Western Blot analysis of GLUL expression in HepG2.
anti-Glutamate-Ammonia Ligase (GLUL) (AA 274-374) antibody (2) anti-Glutamate-Ammonia Ligase (GLUL) (AA 274-374) antibody (Image 2)
Background publications Di Tommaso, Destro, Seok et al.: "The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma." in: Journal of hepatology, Vol. 50, Issue 4, pp. 746-54, 2009 (PubMed).

Xin, Rual, Hirozane-Kishikawa et al.: "Shifted Transversal Design smart-pooling for high coverage interactome mapping." in: Genome research, Vol. 19, Issue 7, pp. 1262-9, 2009 (PubMed).

Jozwik, Pietrzycki, Jozwik et al.: "Expression of enzymes regulating placental ammonia homeostasis in human fetal growth restricted pregnancies." in: Placenta, Vol. 30, Issue 7, pp. 607-12, 2009 (PubMed).

Dal Bello, Rosa, Campanini et al.: "Glutamine synthetase immunostaining correlates with pathologic features of hepatocellular carcinoma and better survival after radiofrequency thermal ablation." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 7, pp. 2157-66, 2010 (PubMed).

Martins-de-Souza, Maccarrone, Wobrock et al.: "Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia." in: Journal of psychiatric research, Vol. 44, Issue 16, pp. 1176-89, 2010 (PubMed).

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