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Aminoacylase 2 (ACY2) (AA 1-101) antibody

Details for Product No. ABIN393318
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Antigen
Synonyms ACY2, ASP, Acy-2, Acy2, nur7, ACY-2, zgc:171507
Epitope
AA 1-101
(5), (4), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(21), (8), (5), (2), (2), (2), (2), (2)
Host
Mouse
(20), (3), (2)
Clonality (Clone)
Monoclonal ()
Application
ELISA, Western Blotting (WB)
(24), (9), (8), (5), (4), (4), (4), (3), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393318
450.00 $
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Immunogen ASPA (NP_000040, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3C11
Isotype IgG2b kappa
Specificity ASPA (NP_000040, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ASPA
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 35735 DA
Gene ID 12406
UniProt NP_000040
Research Area Neurology, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Aminoacylase 2 (ACY2) (AA 1-101) antibody Detection limit for recombinant GST tagged ASPA is approximately 1 ng/mL as a capture antibody.
Background publications Hershfield, Pattabiraman, Madhavarao et al.: "Mutational analysis of aspartoacylase: implications for Canavan disease." in: Brain research, Vol. 1148, pp. 1-14, 2007 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Fares, Badarneh, Abosaleh et al.: "Carrier frequency of autosomal-recessive disorders in the Ashkenazi Jewish population: should the rationale for mutation choice for screening be reevaluated?" in: Prenatal diagnosis, Vol. 28, Issue 3, pp. 236-41, 2008 (PubMed).

Le Coq, Pavlovsky, Malik et al.: "Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue." in: Biochemistry, Vol. 47, Issue 11, pp. 3484-92, 2008 (PubMed).

Joslyn, Ravindranathan, Brush et al.: "Human variation in alcohol response is influenced by variation in neuronal signaling genes." in: Alcoholism, clinical and experimental research, Vol. 34, Issue 5, pp. 800-12, 2010 (PubMed).

Validation Images
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