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Aminoacylase 2 (ACY2) antibody
Alternatives ELISA, Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||ASPA (NP_000040, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: ACY2, ASP aspartoacylase (Canavan disease)|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||ASPA (NP_000040, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||35735 DA|
Background: This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Neurology, Cell Structure|
|Restrictions||For Research Use only|
|Detection limit for recombinant GST tagged ASPA is approximately 1ng/ml as a capture antibody.|
Hershfield, Pattabiraman, Madhavarao et al.: "Mutational analysis of aspartoacylase: implications for Canavan disease." in: Brain research, Vol. 1148, pp. 1-14, 2007 (PubMed).
Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).
Fares, Badarneh, Abosaleh et al.: "Carrier frequency of autosomal-recessive disorders in the Ashkenazi Jewish population: should the rationale for mutation choice for screening be reevaluated?" in: Prenatal diagnosis, Vol. 28, Issue 3, pp. 236-41, 2008 (PubMed).
Le Coq, Pavlovsky, Malik et al.: "Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue." in: Biochemistry, Vol. 47, Issue 11, pp. 3484-92, 2008 (PubMed).
Joslyn, Ravindranathan, Brush et al.: "Human variation in alcohol response is influenced by variation in neuronal signaling genes." in: Alcoholism, clinical and experimental research, Vol. 34, Issue 5, pp. 800-12, 2010 (PubMed).
|Hosts||Rabbit (9), Goat (2)|
|Reactivities||Human (7), Mouse (Murine) (5), Rat (Rattus) (4), Chicken (3), Cow (Bovine) (3), Dog (Canine) (3), Pig (Porcine) (2), Zebrafish (2), Cat (Feline) (1)|
|Applications||Western Blotting (WB) (11), ELISA (5), Flow Cytometry (FACS) (2), Immunofluorescence (IF) (2), Immunohistochemistry (IHC) (2), Immunocytochemistry (ICC) (1), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (1), Immunoprecipitation (IP) (1)|
|Epitopes||N-Term (2), C-Term (1), Internal Region (1)|