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ASPA antibody (Aspartoacylase) (AA 1-101)

Details for Product anti-ASPA Antibody No. ABIN393318, Supplier: Log in to see
Antigen
  • asp
  • acy2
  • ACY-2
  • ASP
  • ACY2
  • Acy-2
  • Acy2
  • nur7
  • zgc:171507
Epitope
AA 1-101
14
11
6
6
3
3
2
2
2
1
1
1
1
1
1
Reactivity
Human
55
24
14
2
2
2
2
2
1
Host
Mouse
35
20
12
Clonality (Clone)
Monoclonal ()
Conjugate
This ASPA antibody is un-conjugated
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
60
21
15
14
11
5
4
3
2
1
1
1
1
Supplier
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Immunogen ASPA (NP_000040, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3C11
Isotype IgG2b kappa
Specificity ASPA (NP_000040, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ASPA (ASPA Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 35735 DA
Gene ID 12406
NCBI Accession NP_000040
Research Area Neurology, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-ASPA antibody (Aspartoacylase) (AA 1-101) (ABIN393318) Detection limit for recombinant GST tagged ASPA is approximately 1 ng/mL as a capture...
Background publications Joslyn, Ravindranathan, Brush et al.: "Human variation in alcohol response is influenced by variation in neuronal signaling genes." in: Alcoholism, clinical and experimental research, Vol. 34, Issue 5, pp. 800-12, 2010 (PubMed).

Le Coq, Pavlovsky, Malik et al.: "Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue." in: Biochemistry, Vol. 47, Issue 11, pp. 3484-92, 2008 (PubMed).

Fares, Badarneh, Abosaleh et al.: "Carrier frequency of autosomal-recessive disorders in the Ashkenazi Jewish population: should the rationale for mutation choice for screening be reevaluated?" in: Prenatal diagnosis, Vol. 28, Issue 3, pp. 236-41, 2008 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Hershfield, Pattabiraman, Madhavarao et al.: "Mutational analysis of aspartoacylase: implications for Canavan disease." in: Brain research, Vol. 1148, pp. 1-14, 2007 (PubMed).