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Cannabinoid Receptor 2 (CNR2) (AA 302-360) antibody

Details for Product No. ABIN393322, Supplier: Log in to see
Antigen
  • CNR2
  • CB2
  • cb2a
  • cb2b
  • CB-2
  • CX5
  • CB2C
  • CNR2C
  • CB2-R
Epitope
AA 302-360
42
13
12
12
10
8
5
3
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
114
19
16
1
1
Host
Mouse
101
15
3
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
5
5
4
3
3
3
2
2
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
77
54
31
30
18
11
8
6
2
1
1
Supplier
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Immunogen CNR2 (NP_001832.1, 302 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3C7
Isotype IgG1 kappa
Specificity CNR2 (NP_001832.1, 302 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CNR2 (CNR2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 39681 DA
Gene ID 12406
NCBI Accession NP_001832
Research Area Neurology, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Cannabinoid Receptor 2 (CNR2) (AA 302-360) antibody (ABIN393322) Western Blot analysis of CNR2 expression in transfected 293T cell line by CNR2 monocl...
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Pinheiro, Bulik, Thornton et al.: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

De Jesús, Hostalot, Garibi et al.: "Opposite changes in cannabinoid CB1 and CB2 receptor expression in human gliomas." in: Neurochemistry international, Vol. 56, Issue 6-7, pp. 829-33, 2010 (PubMed).

Guida, Ligresti, De Filippis et al.: "The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma." in: Endocrinology, Vol. 151, Issue 3, pp. 921-8, 2010 (PubMed).

Carrasquer, Nebane, Williams et al.: "Functional consequences of nonsynonymous single nucleotide polymorphisms in the CB2 cannabinoid receptor." in: Pharmacogenetics and genomics, Vol. 20, Issue 3, pp. 157-66, 2010 (PubMed).