Cannabinoid Receptor 2 (CNR2) (AA 302-360) antibody

Details for Product No. ABIN393322
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Antigen
Synonyms CNR2, CB2, cb2a, cb2b, CB-2, CX5, CB2C, CNR2C, CB2-R
Epitope
AA 302-360
(18), (7), (6), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(71), (17), (16)
Host
Mouse
(71), (6), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(51), (30), (26), (12), (11), (10), (8), (8), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393322
450.00 $
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Immunogen CNR2 (NP_001832.1, 302 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3C7
Isotype IgG1 kappa
Specificity CNR2 (NP_001832.1, 302 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CNR2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 39681 DA
Gene ID 12406
NCBI Accession NP_001832
Research Area Neurology, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Cannabinoid Receptor 2 (CNR2) (AA 302-360) antibody Western Blot analysis of CNR2 expression in transfected 293T cell line by CNR2 monoclonal antibody (M01), clone 3C7. Lane 1: CNR2 transfected lysate(39.7 KDa). Lane 2: Non-transfected lysate.
Background publications Carrasquer, Nebane, Williams et al.: "Functional consequences of nonsynonymous single nucleotide polymorphisms in the CB2 cannabinoid receptor." in: Pharmacogenetics and genomics, Vol. 20, Issue 3, pp. 157-66, 2010 (PubMed).

Guida, Ligresti, De Filippis et al.: "The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma." in: Endocrinology, Vol. 151, Issue 3, pp. 921-8, 2010 (PubMed).

De Jesús, Hostalot, Garibi et al.: "Opposite changes in cannabinoid CB1 and CB2 receptor expression in human gliomas." in: Neurochemistry international, Vol. 56, Issue 6-7, pp. 829-33, 2010 (PubMed).

Pinheiro, Bulik, Thornton et al.: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Validation Images
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