|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Cannabinoid Receptor 2 (CNR2) antibody
|Synonyms||CB2, CX5, CB2-R, CNR2, cb2a, cb2b|
Alternatives ELISA, Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||CNR2 (NP_001832.1, 302 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: CB2, CX5 cannabinoid receptor 2 (macrophage)|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||CNR2 (NP_001832.1, 302 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||39681 DA|
Background: The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Neurology, Cell Structure|
|Restrictions||For Research Use only|
|Western Blot analysis of CNR2 expression in transfected 293T cell line by CNR2 monoclonal antibody (M01), clone 3C7. Lane 1: CNR2 transfected lysate(39.7 KDa). Lane 2: Non-transfected lysate.|
Carrasquer, Nebane, Williams et al.: "Functional consequences of nonsynonymous single nucleotide polymorphisms in the CB2 cannabinoid receptor." in: Pharmacogenetics and genomics, Vol. 20, Issue 3, pp. 157-66, 2010 (PubMed).
Guida, Ligresti, De Filippis et al.: "The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma." in: Endocrinology, Vol. 151, Issue 3, pp. 921-8, 2010 (PubMed).
De Jesús, Hostalot, Garibi et al.: "Opposite changes in cannabinoid CB1 and CB2 receptor expression in human gliomas." in: Neurochemistry international, Vol. 56, Issue 6-7, pp. 829-33, 2010 (PubMed).
Pinheiro, Bulik, Thornton et al.: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).
Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).
|Hosts||Rabbit (47), Goat (4)|
|Reactivities||Human (45), Rat (Rattus) (21), Mouse (Murine) (19)|
|Applications||Western Blotting (WB) (25), Immunofluorescence (IF) (18), ELISA (14), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (8), Immunohistochemistry (IHC) (4), Immunohistochemistry (Paraffin-embedded Sections) pro (IHC (p)+) (4), Flow Cytometry (FACS) (3), Immunocytochemistry (ICC) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Fixed) (IHC (fx)) (1), Immunoprecipitation (IP) (1)|
|Conjugates||Biotin (2), FITC (2), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||C-Term (8), N-Term (4), AA 1-33 (2), Internal Region (2), Cytoplasmic Domain (1)|