Cannabinoid Receptor 2 (CNR2) antibody

Antigen: Cannabinoid Receptor 2 (CNR2)

Synonyms: CB2, CX5, CB2-R, CNR2, cb2a, cb2b

Clonality: Monoclonal (3C7)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393322

Additional Information

Alternative name: CNR2

Gene ID: 1269

UniProt: NP_001832

Immunogen: CNR2 (NP_001832.1, 302 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 3C7

Description: Other names: CB2, CX5 cannabinoid receptor 2 (macrophage)

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: CNR2 (NP_001832.1, 302 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 39681 DA

Comments:

Background: The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Neurology, Cell Structure

Restrictions: For Research Use only

Images

Western Blot analysis of CNR2 expression in transfected 293T cell line by CNR2 monoclonal antibody (M01), clone 3C7. Lane 1: CNR2 transfected lysate(39.7 KDa). Lane 2: Non-transfected lysate.

Publications

Product: Carrasquer, Nebane, Williams et al.: "Functional consequences of nonsynonymous single nucleotide polymorphisms in the CB2 cannabinoid receptor." in: Pharmacogenetics and genomics, Vol. 20, Issue 3, pp. 157-66, 2010 (PubMed).

Guida, Ligresti, De Filippis et al.: "The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma." in: Endocrinology, Vol. 151, Issue 3, pp. 921-8, 2010 (PubMed).

De Jesús, Hostalot, Garibi et al.: "Opposite changes in cannabinoid CB1 and CB2 receptor expression in human gliomas." in: Neurochemistry international, Vol. 56, Issue 6-7, pp. 829-33, 2010 (PubMed).

Pinheiro, Bulik, Thornton et al.: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).