Origin Recognition Complex, Subunit 3 (ORC3) antibody

Antigen: Origin Recognition Complex, Subunit 3 (ORC3)

Synonyms: LAT, ORC3, LATHEO, DmORC3, ORC, l(2)49Fd, l(2)vr6, vr-6, vr6, DmelCG4088, CG4088, ORC3L, MGC128021, orc3, ATORC3, F5E19.30, F5E19_30, ORIGIN RECOGNITION COMPLEX SUBUNIT 3, LOC100226325

Clonality: Monoclonal (3D3)

Host: Mouse

Reactivity: Human

Application: ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN393324

Additional Information

Alternative name: ORC3L

Gene ID: 23595

Immunogen: ORC3L (AAH35494, 602 a.a. ~ 711 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 3D3

Description: Other names: LAT, LATHEO, ORC3 origin recognition complex, subunit 3-like (yeast)

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: ORC3L (AAH35494, 602 a.a. ~ 711 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 82254 DA

Comments:

Background: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Cycle, Neurology, Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged ORC3L is approximately 0.03ng/ml as a capture antibody.

Publications

Product: Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Siddiqui, Stillman: "ATP-dependent assembly of the human origin recognition complex." in: The Journal of biological chemistry, Vol. 282, Issue 44, pp. 32370-83, 2007 (PubMed).

DeRosse, Lencz, Burdick et al.: "The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia." in: Schizophrenia bulletin, Vol. 34, Issue 6, pp. 1047-53, 2008 (PubMed).

Tatsumi, Ezura, Yoshida et al.: "Involvement of human ORC and TRF2 in pre-replication complex assembly at telomeres." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 13, Issue 10, pp. 1045-59, 2008 (PubMed).

Enjuanes, Benavente, Bosch et al.: "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia." in: Cancer research, Vol. 68, Issue 24, pp. 10178-86, 2008 (PubMed).