Origin Recognition Complex, Subunit 3 (ORC3) antibody

Details for Product No. ABIN393324
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Antigen
Synonyms
LAT, LATHEO, ORC3L, Orc3l, CG4088, DmORC3, DmOrc3, Dmel\\CG4088, ORC, ORC3, Orc3, l(2)49Fd, l(2)vr6, vr-6, vr6, orc3, ATORC3, F5E19.30, F5E19_30, ORIGIN RECOGNITION COMPLEX SUBUNIT 3, origin recogniti ... show more
LAT, LATHEO, ORC3L, Orc3l, CG4088, DmORC3, DmOrc3, Dmel\\CG4088, ORC, ORC3, Orc3, l(2)49Fd, l(2)vr6, vr-6, vr6, orc3, ATORC3, F5E19.30, F5E19_30, ORIGIN RECOGNITION COMPLEX SUBUNIT 3, origin recognition complex subunit 3, Afu8g04240, DDBDRAFT_0216767, DDBDRAFT_0233773, DDB_0216767, DDB_0233773, LOC100226325 show less
Reactivity
Human
(24), (2), (2), (1), (1)
Host
Mouse
(11), (8), (5), (4)
Clonality (Clone)
Monoclonal ()
Application
ELISA
(22), (7), (4), (3), (3), (2), (2), (1)
Pubmed 5 references available
Catalog no. ABIN393324
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Immunogen ORC3L (AAH35494, 602 a.a. ~ 711 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D3
Isotype IgG2a kappa
Specificity ORC3L (AAH35494, 602 a.a. ~ 711 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ORC3L
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 82254 DA
Gene ID 12406
Research Area Cell Cycle, Neurology, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Origin Recognition Complex, Subunit 3 (ORC3) antibody Detection limit for recombinant GST tagged ORC3L is approximately 0.03 ng/mL as a capture antibody.
Background publications Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Siddiqui, Stillman: "ATP-dependent assembly of the human origin recognition complex." in: The Journal of biological chemistry, Vol. 282, Issue 44, pp. 32370-83, 2007 (PubMed).

DeRosse, Lencz, Burdick et al.: "The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia." in: Schizophrenia bulletin, Vol. 34, Issue 6, pp. 1047-53, 2008 (PubMed).

Tatsumi, Ezura, Yoshida et al.: "Involvement of human ORC and TRF2 in pre-replication complex assembly at telomeres." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 13, Issue 10, pp. 1045-59, 2008 (PubMed).

Enjuanes, Benavente, Bosch et al.: "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia." in: Cancer research, Vol. 68, Issue 24, pp. 10178-86, 2008 (PubMed).

Hosts (11), (8), (5), (4)
Reactivities (24), (2), (2), (1), (1)
Applications (22), (7), (4), (3), (3), (2), (2), (1)
Epitopes (6), (5), (3), (2), (2), (2)
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