ADAM Metallopeptidase Domain 11 (ADAM11) antibody

Antigen: ADAM Metallopeptidase Domain 11 (ADAM11)

Synonyms: MDC, mdc, mdc11a, xMDC11, DKFZp459F101

Clonality: Monoclonal (3D4)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393325

Additional Information

Alternative name: ADAM11

Gene ID: 4185

UniProt: NP_002381

Immunogen: ADAM11 (NP_002381, 230 a.a. ~ 334 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2b kappa

Clone: 3D4

Description: Other names: MDC ADAM metallopeptidase domain 11

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: ADAM11 (NP_002381, 230 a.a. ~ 334 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 83418 DA

Comments:

Background: This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Signaling, Cell Structure, Cancer, Neurology

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged ADAM11 is approximately 0.1ng/ml as a capture antibody.

Publications

Product: Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Hillman, Green, Brenner: "An unappreciated role for RNA surveillance." in: Genome biology, Vol. 5, Issue 2, pp. R8, 2004 (PubMed).

Brandenberger, Wei, Zhang et al.: "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation." in: Nature biotechnology, Vol. 22, Issue 6, pp. 707-16, 2004 (PubMed).

Fu, Wang, Yang et al.: "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes." in: Genomics, Vol. 84, Issue 1, pp. 205-10, 2004 (PubMed).

Stelzl, Worm, Lalowski et al.: "A human protein-protein interaction network: a resource for annotating the proteome." in: Cell, Vol. 122, Issue 6, pp. 957-68, 2005 (PubMed).