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Creatine Kinase, Brain (CKB) (AA 1-382) antibody

Details for Product No. ABIN393326, Supplier: Log in to see
Antigen
  • bck
  • ckb
  • cb594
  • wu:fj36f10
  • wu:fj37d11
  • b-ck
  • ckbb
  • CKB
  • Chetk
  • Chkl
  • B-CK
  • CKBB
  • Bck
  • Ck-3
  • Ck3
  • Ckbb
  • Ckbr
Epitope
AA 1-382
29
20
20
9
4
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
126
28
27
12
3
2
2
2
2
2
1
1
1
Host
Mouse
92
36
19
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
18
10
5
5
5
5
1
Application
Immunofluorescence (IF)
96
85
15
13
12
12
11
6
5
3
3
3
3
2
1
1
1
1
Supplier
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Immunogen CKB (AAH01190, 1 a.a. ~ 382 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D5-3D11
Isotype IgG1 kappa
Specificity CKB (AAH01190, 1 a.a. ~ 382 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CKB (CKB Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 42644 DA
Gene ID 12406
Research Area Neurology, Cell Structure
Pathways
Comment

Background: The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized.

Restrictions For Research Use only
Concentration 1mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Immunofluorescence (IF) image for anti-Creatine Kinase, Brain (CKB) (AA 1-382) antibody (ABIN393326) Immunofluorescence of monoclonal antibody to CKB on HeLa cell (antibody concentratio...
Background publications Steen, Wilczak, Hoogduin et al.: "Reduced creatine kinase B activity in multiple sclerosis normal appearing white matter." in: PLoS ONE, Vol. 5, Issue 5, pp. e10811, 2010 (PubMed).

Kim, Amante, Moody et al.: "Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease." in: Biochimica et biophysica acta, Vol. 1802, Issue 7-8, pp. 673-81, 2010 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Martins-de-Souza, Gattaz, Schmitt et al.: "Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation." in: BMC psychiatry, Vol. 9, pp. 17, 2009 (PubMed).

Martins-de-Souza, Gattaz, Schmitt et al.: "Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia." in: European archives of psychiatry and clinical neuroscience, Vol. 259, Issue 3, pp. 151-63, 2009 (PubMed).