Creatine Kinase, Brain (CKB) (AA 1-382) antibody

Details for Product No. ABIN393326
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Antigen
Synonyms bck, ckb, cb594, wu:fj36f10, wu:fj37d11, b-ck, ckbb, CKB, Chetk, Chkl, B-CK, CKBB, Bck, Ck-3, Ck3, Ckbb, Ckbr
Epitope
AA 1-382
(14), (10), (6), (6), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(102), (30), (27), (12), (12), (6), (2), (1), (1)
Host
Mouse
(72), (34), (9)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(8), (5), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF)
(79), (60), (15), (15), (15), (10), (10), (9), (8), (5), (4), (4), (4), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393326
450.00 $
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Immunogen CKB (AAH01190, 1 a.a. ~ 382 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D5-3D11
Isotype IgG1 kappa
Specificity CKB (AAH01190, 1 a.a. ~ 382 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CKB
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 42644 DA
Gene ID 12406
Research Area Neurology, Cell Structure
Comment

Background: The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized.

Restrictions For Research Use only
Concentration 1mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Creatine Kinase, Brain (CKB) (AA 1-382) antibody Immunofluorescence of monoclonal antibody to CKB on HeLa cell (antibody concentration 30 µg/mL).
Background publications Martins-de-Souza, Gattaz, Schmitt et al.: "Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia." in: European archives of psychiatry and clinical neuroscience, Vol. 259, Issue 3, pp. 151-63, 2009 (PubMed).

Martins-de-Souza, Gattaz, Schmitt et al.: "Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation." in: BMC psychiatry, Vol. 9, pp. 17, 2009 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Kim, Amante, Moody et al.: "Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease." in: Biochimica et biophysica acta, Vol. 1802, Issue 7-8, pp. 673-81, 2010 (PubMed).

Steen, Wilczak, Hoogduin et al.: "Reduced creatine kinase B activity in multiple sclerosis normal appearing white matter." in: PLoS ONE, Vol. 5, Issue 5, pp. e10811, 2010 (PubMed).

Validation Images
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