|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Creatine Kinase, Brain (CKB) antibody
|Synonyms||B-CK, CKBB, Bck, Ck3, Ck-3, Ckbb, bck, ckb, cb594, wu:fj36f10, wu:fj37d11, MGC53426, CKB, b-ck, ckbb, Ckbr, RATCKBR|
Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||CKB (AAH01190, 1 a.a. ~ 382 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: BCK, CKBBcreatine kinase, brain|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||CKB (AAH01190, 1 a.a. ~ 382 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||42644 DA|
Background: The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Neurology, Cell Structure|
|Restrictions||For Research Use only|
|Immunofluorescence of monoclonal antibody to CKB (AT1543a) on HeLa cell . [antibody concentration 30 ug/ml]|
Martins-de-Souza, Gattaz, Schmitt et al.: "Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia." in: European archives of psychiatry and clinical neuroscience, Vol. 259, Issue 3, pp. 151-63, 2009 (PubMed).
Martins-de-Souza, Gattaz, Schmitt et al.: "Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation." in: BMC psychiatry, Vol. 9, pp. 17, 2009 (PubMed).
Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).
Kim, Amante, Moody et al.: "Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease." in: Biochimica et biophysica acta, Vol. 1802, Issue 7-8, pp. 673-81, 2010 (PubMed).
Steen, Wilczak, Hoogduin et al.: "Reduced creatine kinase B activity in multiple sclerosis normal appearing white matter." in: PLoS ONE, Vol. 5, Issue 5, pp. e10811, 2010 (PubMed).