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Neuro-Oncological Ventral Antigen 1 (NOVA1) (AA 408-508) antibody

Details for Product No. ABIN393331, Supplier: Login to see
Antigen
  • NOVA1
  • si:ch211-222c22.9
  • Nova-1
  • 9430099M15Rik
  • G630039L02
Epitope
AA 408-508
13
9
4
4
3
2
2
2
1
1
1
1
1
1
Reactivity
Human
63
20
20
3
2
1
1
1
1
1
1
Host
Mouse
36
19
8
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
50
25
11
9
8
5
3
1
Supplier
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Immunogen NOVA1 (NP_002506, 408 a.a. ~ 508 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3F3
Isotype IgG2a kappa
Specificity NOVA1 (NP_002506, 408 a.a. ~ 508 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name NOVA1 (NOVA1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 52056 DA
Gene ID 12406
NCBI Accession NP_002506
Research Area Cancer, Neurology, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Neuro-Oncological Ventral Antigen 1 (NOVA1) (AA 408-508) antibody (ABIN393331) NOVA1 monoclonal antibody (M07), clone 3F3 Western Blot analysis of NOVA1 expression ...
Background publications Alkelai, Greenbaum, Rigbi et al.: "Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients." in: Psychopharmacology, Vol. 206, Issue 3, pp. 491-9, 2009 (PubMed).

Vasan, Glazer, Felix et al.: "Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data." in: JAMA : the journal of the American Medical Association, Vol. 302, Issue 2, pp. 168-78, 2009 (PubMed).

Anney, Lasky-Su, ODúshláine et al.: "Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 147B, Issue 8, pp. 1369-78, 2008 (PubMed).

Stich, Rasiah, Rauer: "Paraneoplastic antibody during follow-up of a patient with anti-Ri-associated paraneoplastic neurological syndrome." in: Acta neurologica Scandinavica, Vol. 119, Issue 5, pp. 338-40, 2009 (PubMed).

Ratti, Fallini, Colombrita et al.: "Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV." in: The Journal of biological chemistry, Vol. 283, Issue 12, pp. 7531-41, 2008 (PubMed).