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Details for Product No. ABIN393331

Neuro-Oncological Ventral Antigen 1 (NOVA1) antibody

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Antigen
Synonyms Nova-1, si:ch211-222c22.9, G630039L02, 9430099M15Rik, NOVA1
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN393331
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen NOVA1 (NP_002506, 408 a.a. ~ 508 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3F3
Isotype IgG2a kappa
Specificity NOVA1 (NP_002506, 408 a.a. ~ 508 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name NOVA1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 52056 DA
Gene ID 12406
UniProt NP_002506
Research Area Cancer, Neurology, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Ratti, Fallini, Colombrita et al.: "Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV." in: The Journal of biological chemistry, Vol. 283, Issue 12, pp. 7531-41, 2008 (PubMed).

Stich, Rasiah, Rauer: "Paraneoplastic antibody during follow-up of a patient with anti-Ri-associated paraneoplastic neurological syndrome." in: Acta neurologica Scandinavica, Vol. 119, Issue 5, pp. 338-40, 2009 (PubMed).

Anney, Lasky-Su, ODúshláine et al.: "Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 147B, Issue 8, pp. 1369-78, 2008 (PubMed).

Vasan, Glazer, Felix et al.: "Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data." in: JAMA : the journal of the American Medical Association, Vol. 302, Issue 2, pp. 168-78, 2009 (PubMed).

Alkelai, Greenbaum, Rigbi et al.: "Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients." in: Psychopharmacology, Vol. 206, Issue 3, pp. 491-9, 2009 (PubMed).

Alternatives for antigen "Neuro-Oncological Ventral Antigen 1 (NOVA1)", type "Antibodies"
Hosts (24), (8), (8)
Reactivities (35), (17), (16), (12), (12), (2), (2), (1)
Applications (29), (18), (10), (8), (3), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (3), (2), (2), (1), (1), (1), (1), (1)
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