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Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) (AA 1861-1961) antibody

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Synonyms SCN3A, nav1.3, Gm1000, Nav1.3, SCIII, Scn2a, NAC3
AA 1861-1961
(6), (3), (2), (2), (1), (1)
(32), (15), (14)
(28), (5)
Clonality (Clone)
Monoclonal ()
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
ELISA, Western Blotting (WB)
(15), (11), (9), (7), (7), (1), (1)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen SCN3A (NP_008853, 1861 a.a. ~ 1961 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3F3
Isotype IgG2b kappa
Specificity SCN3A (NP_008853, 1861 a.a. ~ 1961 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SCN3A (SCN3A Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 226294 DA
Gene ID 12406
NCBI Accession NP_008853
Research Area Cell Structure, Neurology
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) (AA 1861-1961) antibody (ABIN393332) Detection limit for recombinant GST tagged SCN3A is approximately 0.3 ng/mL as a capt...
Background publications Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Siqueira, Alves, Malpartida et al.: "Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia." in: Neuroscience, Vol. 164, Issue 2, pp. 573-7, 2009 (PubMed).

Kwan, Poon, Ng et al.: "Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression." in: Pharmacogenetics and genomics, Vol. 18, Issue 11, pp. 989-98, 2008 (PubMed).

Martin, Tang, Ta et al.: "Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences." in: Genomics, Vol. 90, Issue 2, pp. 225-35, 2007 (PubMed).

Catterall, Goldin, Waxman: "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 397-409, 2005 (PubMed).

Catalog No. ABIN393332
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