Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) antibody

Antigen: Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A)

Synonyms: SCN3A, nav1.3

Clonality: Monoclonal (3F3)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393332

Additional Information

Alternative name: SCN3A

Gene ID: 6328

UniProt: NP_008853

Immunogen: SCN3A (NP_008853, 1861 a.a. ~ 1961 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2b kappa

Clone: 3F3

Description: Other names: NAC3 sodium channel, voltage-gated, type III, alpha

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: SCN3A (NP_008853, 1861 a.a. ~ 1961 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 226294 DA

Comments:

Background: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Structure, Neurology

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged SCN3A is approximately 0.3ng/ml as a capture antibody.

Publications

Product: Catterall, Goldin, Waxman: "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 397-409, 2005 (PubMed).

Martin, Tang, Ta et al.: "Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences." in: Genomics, Vol. 90, Issue 2, pp. 225-35, 2007 (PubMed).

Kwan, Poon, Ng et al.: "Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression." in: Pharmacogenetics and genomics, Vol. 18, Issue 11, pp. 989-98, 2008 (PubMed).

Siqueira, Alves, Malpartida et al.: "Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia." in: Neuroscience, Vol. 164, Issue 2, pp. 573-7, 2009 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).