Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) antibody

Details for Product No. ABIN393332
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Antigen
Synonyms Gm1000, Nav1.3, SCIII, Scn2a, NAC3, SCN3A, nav1.3
Reactivity
Human
(28), (14), (14), (12), (12), (12)
Host
Mouse
(25), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(15), (13), (10), (8), (7), (1)
Pubmed 5 references available
Catalog no. ABIN393332
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Immunogen SCN3A (NP_008853, 1861 a.a. ~ 1961 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3F3
Isotype IgG2b kappa
Specificity SCN3A (NP_008853, 1861 a.a. ~ 1961 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SCN3A
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 226294 DA
Gene ID 12406
UniProt NP_008853
Research Area Cell Structure, Neurology
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) antibody Detection limit for recombinant GST tagged SCN3A is approximately 0.3 ng/mL as a capture antibody.
Background publications Catterall, Goldin, Waxman: "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 397-409, 2005 (PubMed).

Martin, Tang, Ta et al.: "Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences." in: Genomics, Vol. 90, Issue 2, pp. 225-35, 2007 (PubMed).

Kwan, Poon, Ng et al.: "Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression." in: Pharmacogenetics and genomics, Vol. 18, Issue 11, pp. 989-98, 2008 (PubMed).

Siqueira, Alves, Malpartida et al.: "Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia." in: Neuroscience, Vol. 164, Issue 2, pp. 573-7, 2009 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Hosts (25), (3)
Reactivities (28), (14), (14), (12), (12), (12)
Applications (15), (13), (10), (8), (7), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (2), (2)
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