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rho GTPase Activating Protein 2 (AA 91-201) antibody

Details for Product No. ABIN393333, Supplier: Login to see
Antigen
  • 0610007I19Rik
  • 0710001E19Rik
  • 1700112L09Rik
  • 2900046J01Rik
  • AI413815
  • ARHGAP2
  • CHN
  • DURS2
  • NC
  • RHOGAP2
  • chimaerin
  • wu:fr89a09
  • zgc:56160
  • zgc:92906
  • N-chimaerin
Epitope
AA 91-201
18
17
5
3
3
2
2
1
1
1
1
Reactivity
Human
74
19
17
1
1
1
1
1
1
1
Host
Mouse
49
25
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
2
2
2
2
2
1
Application
ELISA, Western Blotting (WB)
68
26
14
5
2
2
2
1
Supplier
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Immunogen CHN1 (AAH11393, 91 a.a. ~ 201 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3F8
Isotype IgG1 kappa
Specificity CHN1 (AAH11393, 91 a.a. ~ 201 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CHN1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 53172 DA
Gene ID 12406
Research Area Neurology, Cell Structure
Pathways
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes GTPase-activating protein for p21-rac and a phorbol ester receptor. It plays an important role in ocular motor axon pathfinding. Heterozygous missense mutations in this gene cause Duane's retraction syndrome 2 (DURS2). Multiple transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Volk, Fricke, Strobl et al.: "Analysis of the CHN1 gene in patients with various types of congenital ocular motility disorders." in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, Vol. 248, Issue 9, pp. 1351-7, 2010 (PubMed).

Dick, Meyers, Aliev et al.: "Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 6, pp. 1179-88, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Miyake, Andrews, Fan et al.: "CHN1 mutations are not a common cause of sporadic Duane's retraction syndrome." in: American journal of medical genetics. Part A, Vol. 152A, Issue 1, pp. 215-7, 2009 (PubMed).

Murillo-Correa, Kon-Jara, Engle et al.: "Clinical features associated with an I126M alpha2-chimaerin mutation in a family with autosomal-dominant Duane retraction syndrome." in: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus, Vol. 13, Issue 3, pp. 245-8, 2009 (PubMed).