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rho GTPase Activating Protein 2 (AA 91-201) antibody

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Synonyms 0610007I19Rik, 0710001E19Rik, 1700112L09Rik, 2900046J01Rik, AI413815, ARHGAP2, CHN, DURS2, NC, RHOGAP2, chimaerin, wu:fr89a09, zgc:56160, zgc:92906, N-chimaerin
AA 91-201
(18), (17), (5), (3), (3), (2), (2), (1), (1), (1), (1)
(73), (19), (17), (1), (1), (1), (1), (1), (1), (1)
(48), (25)
Clonality (Clone)
Monoclonal ()
(3), (2), (2), (2), (2), (2), (1)
ELISA, Western Blotting (WB)
(67), (26), (13), (5), (2), (2), (2), (1)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen CHN1 (AAH11393, 91 a.a. ~ 201 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3F8
Isotype IgG1 kappa
Specificity CHN1 (AAH11393, 91 a.a. ~ 201 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CHN1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 53172 DA
Gene ID 12406
Research Area Neurology, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: This gene encodes GTPase-activating protein for p21-rac and a phorbol ester receptor. It plays an important role in ocular motor axon pathfinding. Heterozygous missense mutations in this gene cause Duane's retraction syndrome 2 (DURS2). Multiple transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Volk, Fricke, Strobl et al.: "Analysis of the CHN1 gene in patients with various types of congenital ocular motility disorders." in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, Vol. 248, Issue 9, pp. 1351-7, 2010 (PubMed).

Dick, Meyers, Aliev et al.: "Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 6, pp. 1179-88, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Miyake, Andrews, Fan et al.: "CHN1 mutations are not a common cause of sporadic Duane's retraction syndrome." in: American journal of medical genetics. Part A, Vol. 152A, Issue 1, pp. 215-7, 2009 (PubMed).

Murillo-Correa, Kon-Jara, Engle et al.: "Clinical features associated with an I126M alpha2-chimaerin mutation in a family with autosomal-dominant Duane retraction syndrome." in: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus, Vol. 13, Issue 3, pp. 245-8, 2009 (PubMed).

Catalog No. ABIN393333
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