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Kallikrein 6 antibody (KLK6) (AA 91-190)

Details for Product anti-KLK6 Antibody No. ABIN393337, Supplier: Log in to see
Antigen
  • AI849898
  • BSP
  • Bssp
  • hK6
  • Klk1b21
  • klk6
  • Klk6
  • Klk7
  • KLK8
  • Klk29
  • MSP
  • neurosin
  • Prss9
  • PRSS9
  • PRSS18
  • Prss18
  • rGK-8
  • rk8
  • SP59
Alternatives
anti-Human Kallikrein 6 antibody for Western Blotting
Epitope
AA 91-190
18
13
11
6
6
5
5
4
3
2
2
2
2
1
1
1
1
Reactivity
Human
65
26
25
4
2
1
Host
Mouse
65
19
8
Clonality (Clone)
Monoclonal ()
Conjugate
This Kallikrein 6 antibody is un-conjugated
7
5
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
57
44
16
15
11
8
7
3
2
2
1
1
1
1
1
Supplier
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Immunogen KLK6 (AAH15525, 91 a.a. ~ 190 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4A10
Isotype IgG2a kappa
Specificity KLK6 (AAH15525, 91 a.a. ~ 190 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name KLK6 (KLK6 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 26856 DA
Gene ID 12406
Research Area Cancer, Neurology, Cell Structure
Pathways Complement System
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Kallikrein 6 antibody (KLK6) (AA 91-190) (ABIN393337) Detection limit for recombinant GST tagged KLK6 is approximately 0.3 ng/mL as a captu...
Background publications Han, Lan, Park, Lee, Park, Ahn, Shin, Kang, Koo, Seo, Choi, Ahn, Chanock, Kim, Rothman, Kang: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010

Klein, Halldén, Cronin, Ploner, Wiklund, Bjartell, Stattin, Xu, Scardino, Offit, Vickers, Grönberg, Lilja: "Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer." in: Cancer prevention research (Philadelphia, Pa.), Vol. 3, Issue 5, pp. 611-9, 2010

Rajaraman, Brenner, Neta, Pfeiffer, Wang, Yeager, Thomas, Fine, Linet, Rothman, Chanock, Inskip: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010

White, Mathews, Yousef, Prizada, Popadiuk, Doré: "KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma." in: British journal of cancer, Vol. 101, Issue 7, pp. 1107-13, 2009

Sardana, Diamandis: "The kallikrein family of proteins as urinary biomarkers for the detection of prostate cancer." in: Clinical biochemistry, Vol. 42, Issue 13-14, pp. 1483-6, 2009