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ADAM2 antibody (ADAM Metallopeptidase Domain 2) (AA 376-476)

Details for Product anti-ADAM2 Antibody No. ABIN393338, Supplier: Log in to see
Antigen
  • AI323749
  • Ftnb
  • Ph30-beta
  • CRYN1
  • CRYN2
  • CT15
  • FTNB
  • PH-30b
  • PH30
  • PH30-beta
  • PH-30
Epitope
AA 376-476
4
3
3
2
2
2
2
1
1
1
Reactivity
Human
27
6
3
Host
Mouse
20
9
Clonality (Clone)
Monoclonal ()
Conjugate
This ADAM2 antibody is un-conjugated
1
Application
ELISA, Western Blotting (WB)
26
13
2
2
1
1
1
Supplier
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Immunogen ADAM2 (NP_001455, 376 a.a. ~ 476 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4A2
Isotype IgG2a kappa
Specificity ADAM2 (NP_001455, 376 a.a. ~ 476 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ADAM2 (ADAM2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 82457 DA
Gene ID 12406
NCBI Accession NP_001455
Research Area Cell Signaling, Cell Structure, Neurology
Pathways
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-ADAM2 antibody (ADAM Metallopeptidase Domain 2) (AA 376-476) (ABIN393338) Detection limit for recombinant GST tagged ADAM2 is approximately 0.1 ng/mL as a capt...
Background publications Depa-Martynów, Kempisty, Lianeri et al.: "Association between fertilin beta, protamines 1 and 2 and spermatid-specific linker histone H1-like protein mRNA levels, fertilization ability of human spermatozoa, and quality of preimplantation embryos." in: Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society, Vol. 45 Suppl 1, pp. S79-85, 2008 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Eto, Huet, Tarui et al.: "Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions." in: The Journal of biological chemistry, Vol. 277, Issue 20, pp. 17804-10, 2002 (PubMed).

Ikawa, Nakanishi, Yamada et al.: "Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility." in: Developmental biology, Vol. 240, Issue 1, pp. 254-61, 2002 (PubMed).