ADAM Metallopeptidase Domain 2 (ADAM2) antibody

Details for Product No. ABIN393338
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Antigen
Synonyms CRYN1, CRYN2, CT15, FTNB, PH-30b, PH30, PH30-beta, AI323749, Ftnb, Ph30-beta, PH-30
Reactivity
Human
(30), (2)
Host
Mouse
(25), (8)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(19), (15), (10), (9), (3), (2), (1)
Pubmed 5 references available
Catalog no. ABIN393338
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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  • +1 404 474 4654
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Immunogen ADAM2 (NP_001455, 376 a.a. ~ 476 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4A2
Isotype IgG2a kappa
Specificity ADAM2 (NP_001455, 376 a.a. ~ 476 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ADAM2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 82457 DA
Gene ID 12406
UniProt NP_001455
Research Area Cell Signaling, Cell Structure, Neurology
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-ADAM Metallopeptidase Domain 2 (ADAM2) antibody Detection limit for recombinant GST tagged ADAM2 is approximately 0.1 ng/mL as a capture antibody.
Background publications Ikawa, Nakanishi, Yamada et al.: "Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility." in: Developmental biology, Vol. 240, Issue 1, pp. 254-61, 2002 (PubMed).

Eto, Huet, Tarui et al.: "Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions." in: The Journal of biological chemistry, Vol. 277, Issue 20, pp. 17804-10, 2002 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Depa-Martynów, Kempisty, Lianeri et al.: "Association between fertilin beta, protamines 1 and 2 and spermatid-specific linker histone H1-like protein mRNA levels, fertilization ability of human spermatozoa, and quality of preimplantation embryos." in: Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society, Vol. 45 Suppl 1, pp. S79-85, 2008 (PubMed).

Hosts (25), (8)
Reactivities (30), (2)
Applications (19), (15), (10), (9), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (2), (2), (2), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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