Interleukin 1 alpha (IL1A) (AA 172-271) antibody

Details for Product No. ABIN393341
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Antigen
Synonyms Il-1, Il-1a, IL-1 alpha, IL-1A, IL1, IL1-ALPHA, IL1F1, IL-1alpha, L1A
Epitope
AA 172-271
(8), (7), (5), (5), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(168), (99), (50), (16), (16), (14), (4), (4), (4), (4), (1), (1), (1)
Host
Mouse
(171), (74), (17), (13), (5), (4), (3), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(45), (23), (7), (7), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(187), (187), (55), (39), (36), (29), (27), (21), (21), (21), (9), (9), (3), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393341
450.00 $
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Immunogen IL1A (AAH13142, 172 a.a. ~ 271 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4B8
Isotype IgG1 kappa
Specificity IL1A (AAH13142, 172 a.a. ~ 271 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name IL1A
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 30607 DA
Gene ID 12406
Research Area Neurology, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Szabó, Tax, Kis et al.: "Interleukin-1A +4845(G> T) polymorphism is a factor predisposing to acne vulgaris." in: Tissue antigens, Vol. 76, Issue 5, pp. 411-5, 2010 (PubMed).

Romero, Friel, Velez Edwards et al.: "A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)." in: American journal of obstetrics and gynecology, Vol. 203, Issue 4, pp. 361.e1-361.e30, 2010 (PubMed).

Shimada, Miyagawa, Kawashima et al.: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).

Levine, Singer, Sinsheimer et al.: "CCL3 genotype and current depression increase risk of HIV-associated dementia." in: Neurobehavioral HIV medicine, Vol. 1, pp. 1-7, 2012 (PubMed).

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