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Distal-Less Homeobox Protein 2 (AA 1-110) antibody

Details for Product No. ABIN393342, Supplier: Log in to see
Antigen
  • TES-1
  • TES1
  • AW121999
  • Dlx-2
  • Tes-1
  • Dlx5
  • X-dll2
  • dll4
  • tes-1
  • tes1
  • distal-less homeobox 2
  • DLX2
  • Dlx2
  • dlx2
Epitope
AA 1-110
19
15
10
6
3
3
2
2
2
1
1
1
Reactivity
Human
68
25
10
4
3
2
1
1
Host
Mouse
36
35
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Western Blotting (WB)
68
51
27
21
5
3
1
1
1
Options
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Immunogen DLX2 (NP_004396, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4B9
Isotype IgG2a kappa
Specificity DLX2 (NP_004396, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name DLX2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 34243 DA
Gene ID 12406
NCBI Accession NP_004396
Research Area Neurology, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Distal-Less Homeobox Protein 2 (AA 1-110) antibody (ABIN393342) DLX2 monoclonal antibody (M02), clone 4B9 Western Blot analysis of DLX2 expression in...
Immunohistochemistry (IHC) image for anti-Distal-Less Homeobox Protein 2 (AA 1-110) antibody (ABIN393342) anti-Distal-Less Homeobox Protein 2 (AA 1-110) antibody (Image 2)
Background publications Jugessur, Shi, Gjessing, Lie, Wilcox, Weinberg, Christensen, Boyles, Daack-Hirsch, Nguyen, Christiansen, Lidral, Murray: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Yerges, Klei, Cauley, Roeder, Kammerer, Moffett, Ensrud, Nestlerode, Marshall, Hoffman, Lewis, Lang, Barrett-Connor, Ferrell, Orwoll, Zmuda: "High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 24, Issue 12, pp. 2039-49, 2009 (PubMed).

Liu, Novosedlik, Wang, Hudson, Cohen, Chudley, Forster-Gibson, Lewis, Holden: "The DLX1and DLX2 genes and susceptibility to autism spectrum disorders." in: European journal of human genetics : EJHG, Vol. 17, Issue 2, pp. 228-35, 2009 (PubMed).

Laroche, Ramoz, Leroy, Fortin, Rousselot-Paillet, Philippe, Colleaux, Bresson, Mogenet, Golse, Mouren-Simeoni, Gorwood, Galli, Simonneau, Krebs, Robel: "Polymorphisms of coding trinucleotide repeats of homeogenes in neurodevelopmental psychiatric disorders." in: Psychiatric genetics, Vol. 18, Issue 6, pp. 295-301, 2008 (PubMed).

Espinoza, Ganga, Vadlamudi, Martin, Brooks, Semina, Murray, Amendt: "Protein kinase C phosphorylation modulates N- and C-terminal regulatory activities of the PITX2 homeodomain protein." in: Biochemistry, Vol. 44, Issue 10, pp. 3942-54, 2005 (PubMed).