Distal-Less Homeobox Protein 2 antibody

Antigen: Distal-Less Homeobox Protein 2

Clonality: Monoclonal (4B9)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393342

Additional Information

Alternative name: DLX2

Gene ID: 1746

UniProt: NP_004396

Immunogen: DLX2 (NP_004396, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 4B9

Description: Other names: TES1, TES1 distal-less homeobox 2

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: DLX2 (NP_004396, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 34243 DA

Comments:

Background: Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Neurology, Cell Structure

Restrictions: For Research Use only

Images

DLX2 monoclonal antibody (M02), clone 4B9 Western Blot analysis of DLX2 expression in NIH/3T3 ( Cat # L018V1 ). Immunoperoxidase of monoclonal antibody to DLX2 ( Cat # AT1776a ) on formalin-fixed paraffin-embedded human lung. [antibody concentration 1 ug/ml]

anti-Distal-Less Homeobox Protein 2 antibody (Image 2)

Publications

Product: Espinoza, Ganga, Vadlamudi et al.: "Protein kinase C phosphorylation modulates N- and C-terminal regulatory activities of the PITX2 homeodomain protein." in: Biochemistry, Vol. 44, Issue 10, pp. 3942-54, 2005 (PubMed).

Liu, Novosedlik, Wang et al.: "The DLX1and DLX2 genes and susceptibility to autism spectrum disorders." in: European journal of human genetics : EJHG, Vol. 17, Issue 2, pp. 228-35, 2009 (PubMed).

Laroche, Ramoz, Leroy et al.: "Polymorphisms of coding trinucleotide repeats of homeogenes in neurodevelopmental psychiatric disorders." in: Psychiatric genetics, Vol. 18, Issue 6, pp. 295-301, 2008 (PubMed).

Yerges, Klei, Cauley et al.: "High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 24, Issue 12, pp. 2039-49, 2009 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).