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Corin antibody (Corin, Serine Peptidase) (AA 616-716)

Details for Product anti-CORIN Antibody No. ABIN393353, Supplier: Login to see New
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Synonyms CORIN, CG2105, Dmel\\CG2105, SP75, LOC559109, AV273130, Lrp4, ATC2, CRN, PEE5, TMPRSS10
AA 616-716
(14), (13), (9), (6), (5), (4), (4), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1)
(55), (28), (22)
(67), (4), (1)
Clonality (Clone)
Monoclonal ()
This Corin antibody is un-conjugated
(6), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
ELISA, Western Blotting (WB)
(47), (41), (15), (12), (12), (11), (2), (1)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen CORIN (NP_006578, 616 a.a. ~ 716 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5B6
Isotype IgG1 kappa
Specificity CORIN (NP_006578, 616 a.a. ~ 716 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CORIN (CORIN Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 116565 DA
Gene ID 12406
NCBI Accession NP_006578
Research Area Cell Structure, Neurology
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Corin antibody (Corin, Serine Peptidase) (AA 616-716) (ABIN393353) Detection limit for recombinant GST tagged CORIN is approximately 3 ng/mL as a captur...
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Rame, Tam, McNamara et al.: "Dysfunctional corin i555(p568) allele is associated with impaired brain natriuretic peptide processing and adverse outcomes in blacks with systolic heart failure: results from the Genetic Risk Assessment in Heart Failure substudy." in: Circulation. Heart failure, Vol. 2, Issue 6, pp. 541-8, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Fox, Collard, Shernan et al.: "Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting." in: Anesthesiology, Vol. 110, Issue 4, pp. 738-47, 2009 (PubMed).

Wang, Liao, Fukuda et al.: "Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity." in: Circulation research, Vol. 103, Issue 5, pp. 502-8, 2008 (PubMed).

Catalog No. ABIN393353
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