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Corin, Serine Peptidase (CORIN) antibody

Details for Product No. ABIN393353
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Antigen
Synonyms ATC2, CRN, Lrp4, PEE5, TMPRSS10, AV273130, CORIN, CG2105, Dmel\\CG2105, SP75, LOC559109
Reactivity
Human
(35), (24), (22), (16), (16), (1)
Host
Mouse
(43), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(31), (23), (13), (11), (9), (7), (4), (2), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393353
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen CORIN (NP_006578, 616 a.a. ~ 716 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5B6
Isotype IgG1 kappa
Specificity CORIN (NP_006578, 616 a.a. ~ 716 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CORIN
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 116565 DA
Gene ID 12406
UniProt NP_006578
Research Area Cell Structure, Neurology
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Corin, Serine Peptidase (CORIN) antibody Detection limit for recombinant GST tagged CORIN is approximately 3 ng/mL as a capture antibody.
Background publications Wang, Liao, Fukuda et al.: "Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity." in: Circulation research, Vol. 103, Issue 5, pp. 502-8, 2008 (PubMed).

Fox, Collard, Shernan et al.: "Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting." in: Anesthesiology, Vol. 110, Issue 4, pp. 738-47, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Rame, Tam, McNamara et al.: "Dysfunctional corin i555(p568) allele is associated with impaired brain natriuretic peptide processing and adverse outcomes in blacks with systolic heart failure: results from the Genetic Risk Assessment in Heart Failure substudy." in: Circulation. Heart failure, Vol. 2, Issue 6, pp. 541-8, 2009 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN393353
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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