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Corin antibody (Corin, Serine Peptidase) (AA 616-716)

Details for Product anti-CORIN Antibody No. ABIN393353, Supplier: Log in to see
Antigen
  • CORIN
  • CG2105
  • Dmel\\CG2105
  • SP75
  • LOC559109
  • AV273130
  • Lrp4
  • ATC2
  • CRN
  • PEE5
  • TMPRSS10
Epitope
AA 616-716
14
13
9
5
5
3
3
3
2
2
2
2
2
2
1
1
1
Reactivity
Human
51
26
20
Host
Mouse
59
4
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Corin antibody is un-conjugated
5
4
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
39
34
11
9
6
6
1
1
Supplier
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Immunogen CORIN (NP_006578, 616 a.a. ~ 716 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5B6
Isotype IgG1 kappa
Specificity CORIN (NP_006578, 616 a.a. ~ 716 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CORIN (CORIN Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 116565 DA
Gene ID 12406
NCBI Accession NP_006578
Research Area Cell Structure, Neurology
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Corin antibody (Corin, Serine Peptidase) (AA 616-716) (ABIN393353) Detection limit for recombinant GST tagged CORIN is approximately 3 ng/mL as a captur...
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Rame, Tam, McNamara et al.: "Dysfunctional corin i555(p568) allele is associated with impaired brain natriuretic peptide processing and adverse outcomes in blacks with systolic heart failure: results from the Genetic Risk Assessment in Heart Failure substudy." in: Circulation. Heart failure, Vol. 2, Issue 6, pp. 541-8, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Fox, Collard, Shernan et al.: "Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting." in: Anesthesiology, Vol. 110, Issue 4, pp. 738-47, 2009 (PubMed).

Wang, Liao, Fukuda et al.: "Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity." in: Circulation research, Vol. 103, Issue 5, pp. 502-8, 2008 (PubMed).