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Quinolinate Phosphoribosyltransferase (QPRT) (AA 198-298) antibody

Details for Product No. ABIN393358, Supplier: Log in to see
Antigen
  • ECK0108
  • JW0105
  • VF2184
  • QPRTase
  • 2410027J01Rik
  • AI647766
Epitope
AA 198-298
17
15
7
5
2
2
2
2
1
Reactivity
Human
45
1
1
Host
Mouse
23
20
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
1
Application
Western Blotting (WB)
42
19
18
12
6
6
1
Supplier
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Immunogen QPRT (NP_055113, 198 a.a. ~ 298 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5D11
Isotype IgG1 kappa
Specificity QPRT (NP_055113, 198 a.a. ~ 298 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name QPRT (QPRT Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 30816 DA
Gene ID 12406
NCBI Accession NP_055113
Research Area Neurology, Metabolism, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Quinolinate Phosphoribosyltransferase (QPRT) (AA 198-298) antibody (ABIN393358) QPRT monoclonal antibody (M01), clone 5D11 Western Blot analysis of QPRT expression i...
Immunohistochemistry (IHC) image for anti-Quinolinate Phosphoribosyltransferase (QPRT) (AA 198-298) antibody (ABIN393358) anti-Quinolinate Phosphoribosyltransferase (QPRT) (AA 198-298) antibody (Image 2)
Background publications Hinsch, Frank, Döring et al.: "QPRT: a potential marker for follicular thyroid carcinoma including minimal invasive variant; a gene expression, RNA and immunohistochemical study." in: BMC cancer, Vol. 9, pp. 93, 2009 (PubMed).

Liu, Woznica, Catton et al.: "Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens." in: Journal of molecular biology, Vol. 373, Issue 3, pp. 755-63, 2007 (PubMed).

Rual, Venkatesan, Hao et al.: "Towards a proteome-scale map of the human protein-protein interaction network. ..." in: Nature, Vol. 437, Issue 7062, pp. 1173-8, 2005 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Magni, Amici, Emanuelli et al.: "Enzymology of NAD+ homeostasis in man." in: Cellular and molecular life sciences : CMLS, Vol. 61, Issue 1, pp. 19-34, 2004 (PubMed).