Quinolinate Phosphoribosyltransferase (QPRT) antibody

Details for Product No. ABIN393358
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Antigen
Synonyms QPRTase, AI647766, 2410027J01Rik, ECK0108, JW0105, VF2184
Reactivity
Human
(41), (12), (12), (12), (12)
Host
Mouse
(21), (20)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(29), (13), (10), (9), (9), (7), (5), (5), (1)
Pubmed 5 references available
Catalog no. ABIN393358
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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  • +1 404 474 4654
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Immunogen QPRT (NP_055113, 198 a.a. ~ 298 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5D11
Isotype IgG1 kappa
Specificity QPRT (NP_055113, 198 a.a. ~ 298 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name QPRT
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 30816 DA
Gene ID 12406
UniProt NP_055113
Research Area Neurology, Metabolism, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Quinolinate Phosphoribosyltransferase (QPRT) antibody QPRT monoclonal antibody (M01), clone 5D11 Western Blot analysis of QPRT expression in HepG2 on formalin-fixed paraffin-embedded human tonsil (antibody concentration 3 µg/mL).
anti-Quinolinate Phosphoribosyltransferase (QPRT) antibody (2) anti-Quinolinate Phosphoribosyltransferase (QPRT) antibody (Image 2)
Background publications Magni, Amici, Emanuelli et al.: "Enzymology of NAD+ homeostasis in man." in: Cellular and molecular life sciences : CMLS, Vol. 61, Issue 1, pp. 19-34, 2004 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Rual, Venkatesan, Hao et al.: "Towards a proteome-scale map of the human protein-protein interaction network." in: Nature, Vol. 437, Issue 7062, pp. 1173-8, 2005 (PubMed).

Liu, Woznica, Catton et al.: "Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens." in: Journal of molecular biology, Vol. 373, Issue 3, pp. 755-63, 2007 (PubMed).

Hinsch, Frank, Döring et al.: "QPRT: a potential marker for follicular thyroid carcinoma including minimal invasive variant; a gene expression, RNA and immunohistochemical study." in: BMC cancer, Vol. 9, pp. 93, 2009 (PubMed).

Hosts (21), (20)
Reactivities (41), (12), (12), (12), (12)
Applications (29), (13), (10), (9), (9), (7), (5), (5), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (2), (2), (2), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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