Neuro-Oncological Ventral Antigen 1 (NOVA1) (Met10) antibody

Details for Product No. ABIN393361
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Antigen
Synonyms NOVA1, si:ch211-222c22.9, Nova-1, 9430099M15Rik, G630039L02
Epitope
Met10
(7), (6), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(45), (17), (17), (12), (12), (2), (2), (1)
Host
Mouse
(27), (13), (6)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(35), (18), (10), (7), (3), (2), (2), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393361
450.00 $
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Immunogen NOVA1 (NP_002506, 408 a.a. ~ 508 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5D9
Isotype IgG1 kappa
Specificity NOVA1 (NP_002506, 408 a.a. ~ 508 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name NOVA1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 52056 DA
Gene ID 12406
NCBI Accession NP_002506
Research Area Cancer, Neurology, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.

Restrictions For Research Use only
Concentration 0.5mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Neuro-Oncological Ventral Antigen 1 (NOVA1) (Met10) antibody NOVA1 monoclonal antibody (M10), clone 5D9. Western Blot analysis of NOVA1 expression in PC-12.
Background publications Ratti, Fallini, Colombrita et al.: "Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV." in: The Journal of biological chemistry, Vol. 283, Issue 12, pp. 7531-41, 2008 (PubMed).

Stich, Rasiah, Rauer: "Paraneoplastic antibody during follow-up of a patient with anti-Ri-associated paraneoplastic neurological syndrome." in: Acta neurologica Scandinavica, Vol. 119, Issue 5, pp. 338-40, 2009 (PubMed).

Anney, Lasky-Su, ODúshláine et al.: "Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 147B, Issue 8, pp. 1369-78, 2008 (PubMed).

Vasan, Glazer, Felix et al.: "Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data." in: JAMA : the journal of the American Medical Association, Vol. 302, Issue 2, pp. 168-78, 2009 (PubMed).

Alkelai, Greenbaum, Rigbi et al.: "Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients." in: Psychopharmacology, Vol. 206, Issue 3, pp. 491-9, 2009 (PubMed).

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