Neuro-Oncological Ventral Antigen 1 (NOVA1) (Met10) antibody

Antigen: Neuro-Oncological Ventral Antigen 1 (NOVA1)

Synonyms: Nova-1, MGC84002, NOVA1, si:ch211-222c22.9, G630039L02, 9430099M15Rik, nova1, MGC82481

Binding Site: Met10

Clonality: Monoclonal (5D9)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393361

Additional Information

Alternative name: NOVA1

Gene ID: 4857

UniProt: NP_002506

Immunogen: NOVA1 (NP_002506, 408 a.a. ~ 508 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 5D9

Description: Other names: Nova-1neuro-oncological ventral antigen 1

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: NOVA1 (NP_002506, 408 a.a. ~ 508 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 52056 DA

Comments:

Background: This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Concentration: 0.5mg/ml

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cancer, Neurology, Cell Structure

Restrictions: For Research Use only

Images

NOVA1 monoclonal antibody (M10), clone 5D9. Western Blot analysis of NOVA1 expression in PC-12 ( Cat # L012V1 ).

Publications

Product: Ratti, Fallini, Colombrita et al.: "Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV." in: The Journal of biological chemistry, Vol. 283, Issue 12, pp. 7531-41, 2008 (PubMed).

Stich, Rasiah, Rauer: "Paraneoplastic antibody during follow-up of a patient with anti-Ri-associated paraneoplastic neurological syndrome." in: Acta neurologica Scandinavica, Vol. 119, Issue 5, pp. 338-40, 2009 (PubMed).

Anney, Lasky-Su, ODúshláine et al.: "Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 147B, Issue 8, pp. 1369-78, 2008 (PubMed).

Vasan, Glazer, Felix et al.: "Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data." in: JAMA : the journal of the American Medical Association, Vol. 302, Issue 2, pp. 168-78, 2009 (PubMed).

Alkelai, Greenbaum, Rigbi et al.: "Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients." in: Psychopharmacology, Vol. 206, Issue 3, pp. 491-9, 2009 (PubMed).