Potassium Voltage-Gated Channel, Subfamily G, Member 3 (KCNG3) (AA 23-122) antibody

Details for Product No. ABIN393364
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Antigen
Synonyms KCNG3, KV10.1, KV6.3, Kv10.1a, Kv10.1b, Kv10.1, Kv6.3
Epitope
AA 23-122
(8), (7), (4), (2), (2), (1), (1), (1)
Reactivity
Human
(40), (29), (27), (17), (17), (17), (17)
Host
Mouse
(38), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA
(25), (18), (15), (10), (9), (4)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393364
450.00 $
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Immunogen KCNG3 (NP_579875, 23 a.a. ~ 122 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5H2
Isotype IgG2a kappa
Specificity KCNG3 (NP_579875, 23 a.a. ~ 122 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name KCNG3
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 49593 DA
Gene ID 12406
NCBI Accession NP_579875
Research Area Neurology, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Potassium Voltage-Gated Channel, Subfamily G, Member 3 (KCNG3) (AA 23-122) antibody Detection limit for recombinant GST tagged KCNG3 is approximately 0.3 ng/mL as a capture antibody.
Background publications Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Vega-Saenz de Miera: "Modification of Kv2.1 K+ currents by the silent Kv10 subunits." in: Brain research. Molecular brain research, Vol. 123, Issue 1-2, pp. 91-103, 2004 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Gutman, Chandy, Grissmer et al.: "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 473-508, 2005 (PubMed).

Mederos Y Schnitzler, Rinné, Skrobek et al.: "Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4." in: The Journal of biological chemistry, Vol. 284, Issue 7, pp. 4695-704, 2009 (PubMed).

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