Cadherin 18, Type 2 (CDH18) (AA 467-577) antibody

Details for Product No. ABIN393369
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Synonyms B230220E17Rik, Cdh14l, CDH14, CDH14L, CDH24
AA 467-577
(8), (7), (5), (4), (3), (2), (1), (1), (1), (1), (1), (1)
(49), (19), (13), (1)
(39), (10)
Clonality (Clone)
Monoclonal ()
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(37), (28), (11), (10), (9), (2), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Immunogen CDH18 (NP_004925, 467 a.a. ~ 577 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6F7
Isotype IgG2a kappa
Specificity CDH18 (NP_004925, 467 a.a. ~ 577 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CDH18 (CDH18 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 88073 DA
Gene ID 12406
NCBI Accession NP_004925
Research Area Cell Structure, Neurology
Application Notes Western blot = 1:500-1000

Background: This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Cadherin 18, Type 2 (CDH18) (AA 467-577) antibody (ABIN393369) CDH18 monoclonal antibody (M01), clone 6F7 Western Blot analysis of CDH18 expression ...
Immunohistochemistry (IHC) image for anti-Cadherin 18, Type 2 (CDH18) (AA 467-577) antibody (ABIN393369) anti-Cadherin 18, Type 2 (CDH18) (AA 467-577) antibody (Image 2)
Background publications Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Yang, Yuan, Gao et al.: "[Expressions of cadherin molecules CDH18 and PCDH17 in human azoospermic testes]." in: Zhonghua nan ke xue = National journal of andrology, Vol. 15, Issue 12, pp. 1081-4, 2010 (PubMed).

Kimura, Wakamatsu, Suzuki et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ..." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Shimoyama, Tsujimoto, Kitajima et al.: "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins." in: The Biochemical journal, Vol. 349, Issue Pt 1, pp. 159-67, 2001 (PubMed).

Catalog No. ABIN393369
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