Mahogunin, Ring Finger 1 (MGRN1) (AA 477-577) antibody

Details for Product No. ABIN393376
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Antigen
Synonyms RNF156, RGD1311862, 2610042J20Rik, mKIAA0544, md, nc, mgrn1, wu:fi38c03, zgc:55978
Epitope
AA 477-577
(3), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(39), (17), (16), (13), (13), (13), (12), (1), (1), (1)
Host
Mouse
(24), (15)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(27), (11), (10), (10), (6), (3), (3), (2), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393376
450.00 $
Plus shipping costs $45.00

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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen MGRN1 (NP_056061, 477 a.a. ~ 577 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3E1
Isotype IgG2a kappa
Specificity MGRN1 (NP_056061, 477 a.a. ~ 577 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MGRN1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 60753 DA
Gene ID 12406
NCBI Accession NP_056061
Research Area Ubiquitin-related antibodies, Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Mahogunin, Ring Finger 1 (MGRN1) (AA 477-577) antibody Western Blot analysis of MGRN1 expression in transfected 293T cell line by MGRN1 monoclonal antibody (M07), clone 3E1. Lane 1: MGRN1 transfected lysate(63.2 KDa). Lane 2: Non-transfected lysate.
Background publications Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Fernandez, Milne, Pita et al.: "Pigmentation-related genes and their implication in malignant melanoma susceptibility." in: Experimental dermatology, Vol. 18, Issue 7, pp. 634-42, 2009 (PubMed).

Chakrabarti, Hegde: "Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration." in: Cell, Vol. 137, Issue 6, pp. 1136-47, 2009 (PubMed).

Pérez-Oliva, Olivares, Jiménez-Cervantes et al.: "Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas." in: The Journal of biological chemistry, Vol. 284, Issue 46, pp. 31714-25, 2009 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Validation Images
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