Mahogunin, Ring Finger 1 (MGRN1) antibody

Antigen: Mahogunin, Ring Finger 1 (MGRN1)

Synonyms: RNF156, KIAA0544, md, nc, N28182, mKIAA0544, 2610042J20Rik, RGD1311862, MGC68621, MGRN1, mgrn1, LOC553327, MGC139947, MGC55978, MGC174549, zgc:55978, wu:fi38c03

Clonality: Monoclonal (3E1)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393376

Additional Information

Alternative name: MGRN1

Gene ID: 23295

UniProt: NP_056061

Immunogen: MGRN1 (NP_056061, 477 a.a. ~ 577 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 3E1

Description: Other names: CD41B, GP2B, ITGA2B, KIAA0544, RNF156 mahogunin, ring finger 1

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: MGRN1 (NP_056061, 477 a.a. ~ 577 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 60753 DA

Comments:

Background: Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Ubiquitin-related antibodies, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Images

Western Blot analysis of MGRN1 expression in transfected 293T cell line by MGRN1 monoclonal antibody (M07), clone 3E1. Lane 1: MGRN1 transfected lysate(63.2 KDa). Lane 2: Non-transfected lysate.

Publications

Product: Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Fernandez, Milne, Pita et al.: "Pigmentation-related genes and their implication in malignant melanoma susceptibility." in: Experimental dermatology, Vol. 18, Issue 7, pp. 634-42, 2009 (PubMed).

Chakrabarti, Hegde: "Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration." in: Cell, Vol. 137, Issue 6, pp. 1136-47, 2009 (PubMed).

Pérez-Oliva, Olivares, Jiménez-Cervantes et al.: "Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas." in: The Journal of biological chemistry, Vol. 284, Issue 46, pp. 31714-25, 2009 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).