Mahogunin RING Finger Protein 1 antibody (Mahogunin, Ring Finger 1) (AA 477-577)

Details for Product anti-MGRN1 Antibody No. ABIN393376, Supplier: Log in to see
Antigen
  • RNF156
  • RGD1311862
  • 2610042J20Rik
  • mKIAA0544
  • md
  • nc
  • mgrn1
  • wu:fi38c03
  • zgc:55978
  • mahogunin ring finger 1, E3 ubiquitin protein ligase
  • mahogunin, ring finger 1b
  • mahogunin, ring finger 1
  • mahogunin, ring finger 1a
  • MGRN1
  • mgrn1
  • mgrn1b
  • LOC100342669
  • Mgrn1
  • mgrn1a
Alternatives
anti-Human Mahogunin RING Finger Protein 1 antibody for ELISA
Epitope
AA 477-577
5
3
2
2
2
2
2
1
1
1
Reactivity
Human
42
8
8
3
2
2
2
1
1
1
1
1
1
Host
Mouse
25
17
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
39
20
19
8
5
3
2
1
Options
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Immunogen MGRN1 (NP_056061, 477 a.a. ~ 577 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3E1
Isotype IgG2a kappa
Specificity MGRN1 (NP_056061, 477 a.a. ~ 577 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MGRN1 (MGRN1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 60753 DA
Gene ID 12406
NCBI Accession NP_056061
Research Area Ubiquitin-related antibodies, Protein Modifications, Cell Structure
Pathways Regulation of G-Protein Coupled Receptor Protein Signaling
Application Notes Western blot = 1:500-1000
Comment

Background: Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Mahogunin RING Finger Protein 1 antibody (Mahogunin, Ring Finger 1) (AA 477-577) (ABIN393376) Western Blot analysis of MGRN1 expression in transfected 293T cell line by MGRN1 mono...
Background publications Rose, Behm, Drgon, Johnson, Uhl: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Pérez-Oliva, Olivares, Jiménez-Cervantes, García-Borrón: "Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas." in: The Journal of biological chemistry, Vol. 284, Issue 46, pp. 31714-25, 2009 (PubMed).

Chakrabarti, Hegde: "Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration." in: Cell, Vol. 137, Issue 6, pp. 1136-47, 2009 (PubMed).

Fernandez, Milne, Pita, Floristan, Sendagorta, Feito, Avilés, Martin-Gonzalez, Lázaro, Benítez, Ribas: "Pigmentation-related genes and their implication in malignant melanoma susceptibility." in: Experimental dermatology, Vol. 18, Issue 7, pp. 634-42, 2009 (PubMed).

Barbe, Lundberg, Oksvold, Stenius, Lewin, Björling, Asplund, Pontén, Brismar, Uhlén, Andersson-Svahn: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).