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SET Domain, Bifurcated 2 (SETDB2) (AA 620-720) antibody

Details for Product No. ABIN393380, Supplier: Login to see
Antigen
  • C13orf4
  • CLLD8
  • CLLL8
  • KMT1F
  • Clld8
  • Gm293
Epitope
AA 620-720
30
6
3
3
1
1
1
1
1
Reactivity
Human
60
19
16
6
5
5
1
Host
Mouse
28
22
10
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
47
34
11
3
2
2
1
1
1
Supplier
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Immunogen SETDB2 (NP_114121, 620 a.a. ~ 720 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1E2
Isotype IgG2a kappa
Specificity SETDB2 (NP_114121, 620 a.a. ~ 720 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name SETDB2 (SETDB2 Antibody Abstract)
Background Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).
Synonyms: C13orf4, CLLD8, CLLL8, DKFZp586I0123, DKFZp761J1217 SET domain, bifurcated 2
Molecular Weight 81894 DA
Gene ID 83852
NCBI Accession NP_114121
Research Area Signaling, Protein Modifications, Chromatin, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).

Restrictions For Research Use only
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-SET Domain, Bifurcated 2 (SETDB2) (AA 620-720) antibody (ABIN393380) SETDB2 monoclonal antibody (M07), clone 1E2. Western Blot analysis of SETDB2 expressi...
Background publications Falandry, Fourel, Galy et al.: "CLLD8/KMT1F is a lysine methyltransferase that is important for chromosome segregation." in: The Journal of biological chemistry, Vol. 285, Issue 26, pp. 20234-41, 2010 (PubMed).

Genuneit, Cantelmo, Weinmayr et al.: "A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2." in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Vol. 39, Issue 12, pp. 1875-88, 2010 (PubMed).

Kimura, Wakamatsu, Suzuki et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ..." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Dunham, Matthews, Burton et al.: "The DNA sequence and analysis of human chromosome 13. ..." in: Nature, Vol. 428, Issue 6982, pp. 522-8, 2004 (PubMed).