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Details for Product No. ABIN393380

SET Domain, Bifurcated 2 (SETDB2) antibody

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Antigen
Synonyms C13orf4, CLLD8, CLLL8, KMT1F, Clld8, Gm293
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN393380
Quantity 0.05 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen SETDB2 (NP_114121, 620 a.a. ~ 720 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1E2
Isotype IgG2a kappa
Specificity SETDB2 (NP_114121, 620 a.a. ~ 720 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name SETDB2
Background Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).
Synonyms: C13orf4, CLLD8, CLLL8, DKFZp586I0123, DKFZp761J1217 SET domain, bifurcated 2
Molecular Weight 81894 DA
Gene ID 83852
UniProt NP_114121
Research Area Signaling, Protein Modifications, Chromatin, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).

Restrictions For Research Use only
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Dunham, Matthews, Burton et al.: "The DNA sequence and analysis of human chromosome 13." in: Nature, Vol. 428, Issue 6982, pp. 522-8, 2004 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Kimura, Wakamatsu, Suzuki et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Genuneit, Cantelmo, Weinmayr et al.: "A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2." in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Vol. 39, Issue 12, pp. 1875-88, 2010 (PubMed).

Falandry, Fourel, Galy et al.: "CLLD8/KMT1F is a lysine methyltransferase that is important for chromosome segregation." in: The Journal of biological chemistry, Vol. 285, Issue 26, pp. 20234-41, 2010 (PubMed).

Alternatives for antigen "SET Domain, Bifurcated 2 (SETDB2)", type "Antibodies"
Hosts (20), (9), (7)
Reactivities (34), (14), (13), (13), (13), (12)
Applications (22), (20), (9), (2), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (3), (2), (1)
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